Results 161 to 170 of about 356,744 (339)

A DOUBLETIME Kinase Binding Domain on the Drosophila PERIOD Protein Is Essential for Its Hyperphosphorylation, Transcriptional Repression, and Circadian Clock Function [PDF]

, 2007
Eun Young Kim, Hyuk Wan Ko, Wangjie Yu, Paul E. Hardin, Isaac Edery   +4 more
openalex   +1 more source

Tuning the Period of the Mammalian Circadian Clock: Additive and Independent Effects of CK1εTau and Fbxl3Afh Mutations on Mouse Circadian Behavior and Molecular Pacemaking

Journal of Neuroscience, 2011
Circadian pacemaking in the suprachiasmatic nucleus (SCN) revolves around a transcriptional/posttranslational feedback loop in which period (Per) and cryptochrome (Cry) genes are negatively regulated by their protein products.
E. Maywood, J. Chesham, Q. Meng, P. Nolan, A. Loudon, M. Hastings   +5 more
semanticscholar   +1 more source

Chromosome‐level genome assembly and population genomic analysis provide insights into the genetic diversity and adaption of Schizopygopsis younghusbandi on the Tibetan Plateau

Integrative Zoology, EarlyView.
We have constructed the chromosome‐scale genome and investigated the evolutionary genomics of Schizopygopsis younghusbandi, a fish species native to the Yarlung Tsangpo River on the Tibetan Plateau. Our study indicated that this species diverged from other Schizothoracine fish approximately 4.2 million years ago, during the Neogene Tibetan uplift ...
Chaowei ZHOU, Yan ZHOU, Luohao XU, Fei LIU, Luo LEI, He GAO, Junting LI, Suxing FU, Yuting DUAN, Yougang TAN, Weihua MAO, Qiming WANG, Rongzhu ZHOU, Shijun XIAO, Chuan LIU, Haiping LIU   +15 more
wiley   +1 more source

cba‐miR‐222‐3p involved in photoperiod‐induced apoptosis in testes of striped hamsters by targeting TRAF7

Integrative Zoology, EarlyView.
The cba‐miR‐222‐3p affects the MAPK signaling pathway by targeting TRAF7, thereby participating in the induction of apoptosis in the testes of striped hamsters under different photoperiods. Abstract The role of miRNAs in the regulation of seasonal reproduction in rodents, particularly in relation to photoperiod changes, is still poorly understood ...
Shuo WANG, Jinhui XU, Xingchen WANG, Mingdi WANG, Huiliang XUE, Ming WU, Chao FAN, Lei CHEN, Laixiang XU   +8 more
wiley   +1 more source

A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study

Aging Cell, Volume 24, Issue 4, April 2025.
In this study, we describe a novel multi‐omics framework to train saliva‐based DNA methylation (DNAm) biomarkers that are reproducible and biologically interpretable. By leveraging a reliability dataset with replicates across tissues, we demonstrate knowledge transfer from blood DNAm to saliva DNAm data using DNAm proxies of blood proteins (EpiScores).
Lisa J. Schmunk, Toby P. Call, Daniel L. McCartney, Hira Javaid, Waylon J. Hastings, Vanja Jovicevic, Dragoljub Kojadinović, Natacha Tomkinson, Eliska Zlamalova, Kirsty C. McGee, Jack Sullivan, Archie Campbell, Andrew M. McIntosh, Veronika Óvári, Karl Wishart, Christian E. Behrens, Emma Stone, Miloš Gavrilov, Rob Thompson, Hurdle bio‐infrastructure team, Thomas Jackson, Janet M. Lord, Thomas M. Stubbs, Riccardo E. Marioni, Daniel E. Martin‐Herranz, Pierric Descamps, Emily Taylor, Chuck Paiusi, Leona Mc Girr, Ollie Philpott, Ian Robinson, Hector Watson, Ana Magalia, Dave Russell, David Woods   +34 more
wiley   +1 more source

Rapid Circadian Entrainment in Models of Circadian Genes Regulation [PDF]

arXiv, 2019
The light-based minimum-time circadian entrainment problem for mammals, Neurospora, and Drosophila is studied based on the mathematical models of their circadian gene regulation. These models contain high order nonlinear differential equations. Two model simplification methods are applied to these high-order models: the phase response curves (PRC) and ...
arxiv  

Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice

Aging Cell, Volume 24, Issue 5, May 2025.
Over a 10‐week regimen, IMF significantly improved locomotor activity, motor coordination, and muscle strength compared to controls (p < 0.01). Resting‐state fMRI (rsfMRI) demonstrated that IMF modulates brain‐wide functional connectivity, enhancing communication between key brain regions.
Zhuang Liu, Ziyue Zhao, Hongying Du, Qingqing Zhou, Mei Li, Zhu Gui, Jinfeng Wu, Yunling Gao, Ning Zheng, Yu Zhang, Ailian Du, Hongxing Wang, Jie Wang   +12 more
wiley   +1 more source

Dietary Zinc Limitation Dictates Lifespan and Reproduction Trade‐Offs of Drosophila Mothers

Aging Cell, Volume 24, Issue 5, May 2025.
Dietary metal ions significantly influence the lifespan and reproduction of Drosophila females. In this study, we show that not adding any of the metal ions to the diet adversely affects reproduction and lifespan. By contrast, food with no added Zn negatively impacts reproduction but not maternal lifespan, suggesting that female flies stop producing ...
Sweta Sarmah, Hannah Thi‐Hong Hanh Truong, Gawain McColl, Richard Burke, Christen K. Mirth, Matthew D. W. Piper   +5 more
wiley   +1 more source

Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice

Aging Cell, Volume 24, Issue 5, May 2025.
An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone, Jorge J. Mundo, Boahen N. Kwakye, Amber Slaweski, John A. Collins, Qinglin Wu, Margery A. Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V. Risbud   +9 more
wiley   +1 more source

Temporal Regulation of Cytokines by the Circadian Clock

Journal of Immunology Research, 2014
Several parameters of the immune system exhibit oscillations with a period of approximately 24 hours that refers to “circadian rhythms.” Such daily variations in host immune system status might evolve to maximize immune reactions at times when encounters
Atsuhito Nakao
doaj   +1 more source