Results 181 to 190 of about 85,043 (305)

Indocyanine Green Clearance Correlates With Biomarkers Reflecting Key Disease‐Driving Mechanisms in Advanced Chronic Liver Disease and Predicts Acute‐on‐Chronic Liver Failure and Death

Alimentary Pharmacology &Therapeutics, EarlyView.
Indocyanine green clearance by pulse dye densitometry correlates with portal hypertension, systemic inflammation and circulatory dysfunction in advanced chronic liver disease. While diagnostic accuracy for CSPH was limited, ICG‐R15 independently predicted decompensation and ACLF/liver‐related mortality, highlighting its prognostic value across disease ...
Mathias Jachs, Tânia Carvalho, Benedikt Simbrunner, Georg Semmler, Lukas Hartl, Lorenz Balcar, Benedikt Silvester Hofer, Paul Thöne, Nina Dominik, Georg Kramer, Christian Sebesta, Michael Schwarz, David Bauer, Albert F. Stättermayer, Matthias Pinter, Michael Trauner, Thomas Reiberger, Mattias Mandorfer   +17 more
wiley   +1 more source

Modeling the dynamics of hepatic metabolism: the predominance of 12-hour rhythmicity in metabolic adaptation. [PDF]

Cell Mol Life Sci
Matz-Soja M, Körner C, Ott F, Fischer J, Marbach-Breitrück E, Bergmann C, Hofmann U, Shevchenko A, Wallach I, Textoris-Taube K, Mülleder M, Gebhardt R, Berg T, Berndt N.   +13 more
europepmc   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Non-visual opsins and their role in circadian photoentrainment. [PDF]

Eye Vis (Lond)
Buhr ED, Van Gelder RN.
europepmc   +1 more source

Faculty Opinions recommendation of Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2019
openaire   +2 more sources

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

The Circadian Rhythm of Asthma Immune Metabolism. [PDF]

J Immunol Res
Lu M, Cheng F, Zhao X, Wang Z, Chen J, Zhang Y, Huang S, Zhang X, Xue Z, Liu Y, Yao W.   +10 more
europepmc   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Loss of the liver circadian clock affects the expression of intrarenal renin-angiotensin system components. [PDF]

Sci Rep
Hassan SA, Stumpe M, Hui KY, Giraud MN, Albrecht U, Ripperger JA.   +5 more
europepmc   +1 more source