Results 191 to 200 of about 356,744 (339)

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

Biological Reviews, EarlyView.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett, A. Ross Brown, Samuel K. Maynard, Stewart F. Owen, Charles R. Tyler   +4 more
wiley   +1 more source

NEK2 Control of Esophageal Squamous Cell Carcinoma Growth Based on Circadian Oscillation

Cancer Science, Volume 116, Issue 5, Page 1282-1294, May 2025.
Our findings position NEK2 as a time‐dependent oncogene and a potential biomarker in ESCC, highlighting its role in both tumorigenesis and the circadian rhythm. ABSTRACT Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy known for its aggressive nature and unfavorable outcomes.
Boning Zeng, Chao Sun, Nan Li, Qiuling Chen, Manni Rao, Kai Li, Xiaodi Liu, Shouxia Xie, Jiwu Cheng, Shaoxiang Wang, Xiao Wang   +10 more
wiley   +1 more source

The Pro‐Apoptotic Effect of Glucose Restriction in NSCLC via AMPK‐Regulated Circadian Clock Gene Bmal1

Cancer Science, EarlyView.
In this study we investigate the role of the core circadian gene BMAL1 in regulating mechanisms within non‐small cell lung cancer cells, revealing that circadian rhythm disruption may represent another significant factor triggering apoptosis. ABSTRACT The circadian clock is a crucial regulator of mammalian physiology, controlling daily oscillations in ...
Tao Wei, Ying Cheng, Jierong Ge, Manting Zhu, Hong Chen, Qing Feng   +5 more
wiley   +1 more source

Switching Patients With Congenital Adrenal Hyperplasia to Modified‐Release Hydrocortisone Capsules: Relative Bioavailability and Disease Control

Clinical Endocrinology, EarlyView.
ABSTRACT Background Replacement therapy with modified‐release hydrocortisone capsules (MRHC) restores the physiological circadian cortisol rhythm in congenital adrenal hyperplasia (CAH). Aims To determine the relative bioavailability of MRHC and evaluate an optimal protocol to switch CAH patients from standard therapy to MRHC.
Richard John M. Ross, Wiebke Arlt, Aude Brac de la Perriere, Angelica Lindén Hirschberg, Anders Juul, Deborah P. Merke, John D. C. Newell‐Price, Alessandro Prete, D. Aled Rees, Nicole Reisch, Monica Stikkelbroeck, Philippe A. Touraine, Kerry Maltby, Jo Quirke, Helen Coope, John Porter   +15 more
wiley   +1 more source

Infantile Cerebellar‐Retinal Degeneration Associated With Novel ACO2 Variants: Clinical Features and Insights From a Drosophila Model

Clinical Genetics, EarlyView.
Our Translational Loop integrates patient genetic data with Drosophila models to study disease mechanisms. We identified ACO2 variants in a patient linked to ICRD and show that our animal model mirrors key aspects of the disease. These insights help pinpoint therapeutic targets, advancing research toward treatments for rare genetic disorders.
Edgar Buhl, Suchika Garg, Marie Monaghan, Amy Preston, Marcus Likeman, Julianne Dare, Julie Evans, Lucie S. Taylor, Ian Berry, Kathryn Urankar, Paul G. D. Spry, Cathy Williams, Robert W. Taylor, Charlotte L. Alston, James J. L. Hodge, Anirban Majumdar   +15 more
wiley   +1 more source

E74-like factor inhibition induces reacquisition of hormone sensitiveness decreasing period circadian protein homolog 1 expression in prostate cancer cells

, 2015
Kohei Koyama, Kiyoshi Takahara, Teruo Inamoto, Naokazu Ibuki, Koichiro Minami, Hirofumi Uehara, Kazumasa Komura, Takeshi Nishida, Takeshi Sakamoto, Hajime Hirano, Hayahito Nomi, Satoshi Kiyama, Haruhito Azuma   +12 more
openalex   +1 more source

period-1 encodes an ATP-dependent RNA helicase that influences nutritional compensation of the Neurospora circadian clock

Proceedings of the National Academy of Sciences of the United States of America, 2015
Jillian M Emerson, Bradley M. Bartholomai, C. Ringelberg, S. Baker, J. Loros, J. Dunlap   +5 more
semanticscholar   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink, Dominique van Mil, Gozewijn D. Laverman, Hiddo J. L. Heerspink, Ron T. Gansevoort   +4 more
wiley   +1 more source

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source