Results 101 to 110 of about 6,050,140 (310)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Group pairs with periodic cohomology
Journal of Pure and Applied Algebra, 1990 A group pair \((G,{\mathbf S})\) with \({\mathbf S}\) a family of subgroups of \(G\) is said to be periodic if the (relative) cohomology is periodic, i.e. if there is an integer \(q\) such that for all \(k\geq 2\) and for all \(G\)-modules \(A\) one has a natural isomorphism \(H^ k(G,{\mathbf S};A)\equiv H^{k+q}(G,{\mathbf S};A)\).
BIERI, R, TALELLI, O
openaire +3 more sources
Periodic transonic flow and control [PDF]
, 2008 The current understanding of periodic transonic flow is reviewed briefly. The effects of boundary-layer transition, non-adiabatic wall conditions and modifications to the aerofoil surface geometry at the shock interactions on periodic transonic flow are ...
Quest, J. +14 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
New periodic orbits in the solar sail three-body problem [PDF]
, 2011 We identify displaced periodic orbits in the circular restricted three-body problem, wher the third (small) body is a solar sail. In particular, we consider solar sail orbits in the earth-sun system which are high above the exliptic plane.
Biggs, J.D., Waters, T., McInnes, C.R.
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Some reformulations and extensions of the theory of rhythmic canons
Proceedings (European Academy of Sciences and Arts)The algebraic theory of periodic rhythmic canons was developed by the author of the present paper in connection with the study of a special class of rhythmic canons, nowadays referred as “Vuza canons”.
Dan Tudor Vuza
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A numerically reliable approach for the synthesis of periodic FDI filters [PDF]
, 2012 We propose an integrated numerically reliable computational approach to solve fault detection and isolation (FDI) problems for periodic systems. For this purpose, a bank of periodic fault detection filters providing a structured residual set is designed
Varga, Andreas
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source