Results 81 to 90 of about 1,516,190 (385)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

A model for aperiodicity in earthquakes [PDF]

open access: yesNonlinear Processes in Geophysics, 2008
Conditions under which a single oscillator model coupled with Dieterich-Ruina's rate and state dependent friction exhibits chaotic dynamics is studied. Properties of spring-block models are discussed.
B. Erickson, B. Birnir, D. Lavallée
doaj  

Periodic solutions with long period for the Mackey–Glass equation

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2020
The limiting version of the Mackey–Glass delay differential equation $x'(t)=-ax(t)+bf(x(t-1))$ is considered where $a,b$ are positive reals, and $f(\xi)=\xi$ for $\xi\in[0,1)$, $f(1)=1/2$, and $f(\xi)=0$ for $\xi> 1$.
Tibor Krisztin
doaj   +1 more source

Periodic Orbits in Polygonal Billiards

open access: yes, 1996
We review some properties of periodic orbit families in polygonal billiards and discuss in particular a sum rule that they obey. In addition, we provide algorithms to determine periodic orbit families and present numerical results that shed new light on ...
A Selberg   +19 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Existence and Uniqueness of Homoclinic Solution for a Class of Nonlinear Second-Order Differential Equations

open access: yesJournal of Applied Mathematics, 2012
The authors study the existence and uniqueness of a set with 2kT-periodic solutions for a class of second-order differential equations by using Mawhin's continuation theorem and some analysis methods, and then a unique homoclinic orbit is obtained as a ...
Lijuan Chen, Shiping Lu
doaj   +1 more source

Non-contractible periodic orbits in Hamiltonian dynamics on tori

open access: yes, 2017
We show that the presence of one non-degenerate, non-contractible periodic orbit of a Hamiltonian on the standard symplectic torus implies the existence of infinitely many simple non-contractible periodic orbits.Comment: 10 pages, minor revision ...
Orita, Ryuma
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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