Results 81 to 90 of about 17,385 (315)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Bifurcations of periodic orbits and uniform approximations. [PDF]

, 1997
We derive uniform approximations for contributions to Gutzwiller's periodic-orbit sum for the spectral density which are valid close to bifurcations of periodic orbits in systems with mixed phase space.
Schomerus, Henning, Sieber, Martin, Schomerus, H, Sieber, MMA   +3 more
core  

Generation of optimal trajectories for Earth hybrid pole sitters [PDF]

, 2011
A pole-sitter orbit is a closed path that is constantly above one of the Earth's poles, by means of continuous low thrust. This work proposes to hybridize solar sail propulsion and solar electric propulsion (SEP) on the same spacecraft, to enable such a ...
Colin R. McInnes, McInnes, Colin, Ceriotti, Matteo, Ceriotti, M., Matteo Ceriotti, McInnes, C.R.   +5 more
core   +1 more source

Existence and Uniqueness of Homoclinic Solution for a Class of Nonlinear Second-Order Differential Equations

Journal of Applied Mathematics, 2012
The authors study the existence and uniqueness of a set with 2kT-periodic solutions for a class of second-order differential equations by using Mawhin's continuation theorem and some analysis methods, and then a unique homoclinic orbit is obtained as a ...
Lijuan Chen, Shiping Lu
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Reversible Relative Periodic Orbits

Journal of Differential Equations, 2002
The aim of this paper is to extend recently obtained results [\textit{B. Sandstede}, \textit{A. Scheel} and \textit{C. Wulff}, J. Nonlinear Sci. 9, 349--378 (1999; Zbl 0951.35014); \textit{C. Wulff}, \textit{J. S. W. Lamb} and \textit{I. Melbourne}, Ergodic Theory Dyn. Syst.
Lamb, JSW, Wulff, C
openaire   +3 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Displaced periodic orbits with low-thrust propulsion

, 2009
Solar sailing and solar electric technology provide alternative forms of spacecraft propulsion. These propulsion systems can enable exciting new space-science mission concepts such as solar system exploration and deep space observation.
Simo, Jules, McInnes, Colin R., McInnes, C.R.   +2 more
core  

Beyond the Periodic Orbit Theory [PDF]

, 1998
The global constraints on chaotic dynamics induced by the analyticity of smooth flows are used to dispense with individual periodic orbits and derive infinite families of exact sum rules for several simple dynamical systems.
Hansen, K., Vattay, G, Rolf, J.J., Cvitanovic, P, Vattay, G., Rolf, J, Hansen, K, Cvitanovic, P.   +7 more
core   +1 more source

Termination Analysis of Nonlinear Loops and Linear Loops in R^m

工程科学与技术, 2013
:To study the problem of reliability of software in program design,the termination of program was discussed While x∈Ω do{x:=f(x)}end under the condition that Ω is union of finite mutually disjoint closed intervals.
陈敬敏
doaj