Results 91 to 100 of about 1,446,784 (362)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
On the existence of a new type of periodic and quasi-periodic orbits for twist maps of the torus
, 2002 We prove that for a large and important class of $C^1$ twist maps of the torus periodic and quasi-periodic orbits of a new type exist, provided that there are no rotational invariant circles (R.I.C's).
Zanata, S Addas
core +1 more source
Absolutely Periodic Billiard Orbits of Arbitrarily High Order [PDF]
, 2022 Keagan G. Callis
openalex +1 more source
Open Astronomy, 2016 Locating the position of periodic orbits in galaxies is undoubtedly an issue of paramount importance. We reveal the position and the stability of periodic orbits of stars moving in the meridional plane (R, z) of an axially symmetric galactic model with a
Zotos Euaggelos E.
doaj +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Invariant manifolds and orbit control in the solar sail three-body problem [PDF]
, 2008 In this paper we consider issues regarding the control and orbit transfer of solar sails in the circular restricted Earth-Sun system. Fixed points for solar sails in this system have the linear dynamical properties of saddles crossed with centers; thus ...
Colin R. McInnes +6 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Transient periodic behaviour related to a saddle-node bifurcation [PDF]
, 1987 The authors investigate transient periodic orbits of dissipative invertible maps of R2. Such orbits exist just before, in parameter space, a saddle-node pair is formed.
Damme, Ruud van, Valkering, Theo P.
core +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source