Results 81 to 90 of about 9,926,750 (356)

Periodic solutions for a class of second order differential equations

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2013
New results about the existence of periodic solutions for second order differential equations are provided. The method of proof relies on the Schauder's fixed point theorem. Some examples are presented to illustrate the main results.
Weibing Wang, Yan Luo
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Rotating periodic solutions for second order systems with Hartman-type nonlinearity

open access: yesBoundary Value Problems, 2018
In this paper, by a constructive proof based on the homotopy continuation method, we prove that the second order system x″=g(t,x) $x''=g(t,x)$ admits rotating periodic solutions with form u(t+T)=Qu(t) $u(t+T)=Qu(t)$ for any orthogonal matrix Q when the ...
Jian Li, Xiaojun Chang, Yong Li
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Rotating periodic solutions of second order dissipative dynamical systems

open access: yes, 2015
This paper is devoted to the following second order dissipative dynamical system \begin{equation*} u''+cu'+ \nabla g(u)+h(u)=e(t) ~\mbox{in}~\mathbb{R}^n.
Xiaojun Chang, Yong Li
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Multiplicity of Periodic Solutions for a Higher Order Difference Equation

open access: yesAbstract and Applied Analysis, 2014
We study a higher order difference equation. By Lyapunov-Schmidt reduction methods and computations of critical groups, we prove that the equation has four M-periodic solutions.
Ronghui Hu
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

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