Results 71 to 80 of about 285,537 (315)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Periodic solutions for a class of second order differential equations
Electronic Journal of Qualitative Theory of Differential Equations, 2013 New results about the existence of periodic solutions for second order differential equations are provided. The method of proof relies on the Schauder's fixed point theorem. Some examples are presented to illustrate the main results.
Weibing Wang, Yan Luo
doaj +1 more source
, 1997 The discrete-time positive periodic Lyapunov equations have important applications in the balancing and potentially also in the model reduction of discrete-time periodic systems.
A. Varga, Varga, A., Andreas Varga
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Rotating periodic solutions for second order systems with Hartman-type nonlinearity
Boundary Value Problems, 2018 In this paper, by a constructive proof based on the homotopy continuation method, we prove that the second order system x″=g(t,x) $x''=g(t,x)$ admits rotating periodic solutions with form u(t+T)=Qu(t) $u(t+T)=Qu(t)$ for any orthogonal matrix Q when the ...
Jian Li, Xiaojun Chang, Yong Li
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Computational Methods for Periodic Systems - An Overview
, 2001 We present an up-to-date survey of numerical methods for the analysis and design of linear discrete-time periodic systems. The basic tool is the periodic Schur form and its variants, for which a certain form of numerical stability can be ...
IFAC Workshop on Periodic Control Systems (PSYCO 2001) +3 more
core
On computing the zeros of periodic systems
, 2002 We present an effcient and numerically reliable approach to compute the zeros of a periodic system. The zeros are defined in terms of the transfer-function matrix corresponding to an equivalent lifted statespace representation as constant system.
Dooren, P. Van +6 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
On a first order unilateral evolutive periodic problem.
Ratio Mathematica, 1996 We consider the periodic problem related to a first order evolutive variational equation and we study existence of solution.
A Gallo, A. M. Piccirillo
doaj