Results 91 to 100 of about 9,489,153 (244)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Solution of Positive Periodic Discrete Lyapunov Equations with Applications to the Balancing of Periodic Systems. [PDF]

open access: yes, 1997
The discrete-time positive periodic Lyapunov equations have important applications in the balancing and potentially also in the model reduction of discrete-time periodic systems.
A. Varga, Varga, A., Andreas Varga
core   +1 more source

ON PERIODIC SOLUTIONS OF THE SECOND ORDER EQUATION

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The sufficient conditions for the existence of several isolated periodic solutions of the equation are obtained.
V. E. Zhavnerchik
doaj  

Rotating periodic solutions for second order systems with Hartman-type nonlinearity

open access: yesBoundary Value Problems, 2018
In this paper, by a constructive proof based on the homotopy continuation method, we prove that the second order system x″=g(t,x) $x''=g(t,x)$ admits rotating periodic solutions with form u(t+T)=Qu(t) $u(t+T)=Qu(t)$ for any orthogonal matrix Q when the ...
Jian Li, Xiaojun Chang, Yong Li
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

On a first order unilateral evolutive periodic problem.

open access: yesRatio Mathematica, 1996
We consider the periodic problem related to a first order evolutive variational equation and we study existence of solution.
A Gallo, A. M. Piccirillo
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Bifurcations of periodic orbits and uniform approximations. [PDF]

open access: yes, 1997
We derive uniform approximations for contributions to Gutzwiller's periodic-orbit sum for the spectral density which are valid close to bifurcations of periodic orbits in systems with mixed phase space.
Schomerus, Henning, Sieber, Martin
core   +3 more sources

On periodic solutions of fractional-order differential systems with a fixed length of sliding memory

open access: yesJournal of Innovative Applied Mathematics and Computational Sciences, 2021
The fractional-order derivative of a non-constant periodic function is not periodic with the same period. Consequently, any time-invariant fractional-order systems do not have a non-constant periodic solution.
Safa Bourafa   +2 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

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