Results 81 to 90 of about 285,537 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ON PERIODIC SOLUTIONS OF THE SECOND ORDER EQUATION

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The sufficient conditions for the existence of several isolated periodic solutions of the equation are obtained.
V. E. Zhavnerchik
doaj  

Collocation methods for a class of second order initial value problems with oscillatory solutions [PDF]

open access: yes, 1993
We derive and analyse two families of multistep collocation methods for periodic initial-value problems of the form y" = f(x, y); y((^x)o) = yo, y(^1)(xo) = zo involving ordinary differential equations of second order in which the first derivative ...
Booth, Andrew S.
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Multiplicity of Periodic Solutions for a Higher Order Difference Equation

open access: yesAbstract and Applied Analysis, 2014
We study a higher order difference equation. By Lyapunov-Schmidt reduction methods and computations of critical groups, we prove that the equation has four M-periodic solutions.
Ronghui Hu
doaj   +1 more source

Balanced truncation model reduction of periodic systems

open access: yes, 2000
The balanced truncation approach to model reduction is considered for linear discrete-time periodic systems with time-varying dimensions. Stability of the reduced model is proved and a guaranteed additive bound is derived for the approximation error ...
Varga, Andras
core  

Periodic solutions for $n$-th order delay differential equations with damping terms [PDF]

open access: yes, 2011
summary:By using the coincidence degree theory of Mawhin, we study the existence of periodic solutions for $n$ th order delay differential equations with damping terms $x^{(n)}(t)=\sum \limits ^{s}_{i=1}b_{i}[x^{(i)}(t)]^{2k-1}+ f(x(t-\tau (t)))+p(t ...
Pan, Lijun
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The Sarkovskii order for periodic continua II

open access: yesTopology and its Applications, 2007
\textit{A. N. Sharkovskij} [Ukr. Mat. Zh. 16, 61--71 (1964; Zbl 0122.17504)] proved that if \(p \prec q\) according to the following ordering of the positive integers, then for any map of the real line to itself with a periodic point of period \(p\), there exists a periodic point of period \(q\).
openaire   +2 more sources

Computation of minimal order dynamic covers for predic systems

open access: yes, 2007
- Minimal dimension dynamic covers play an important role in solving the structural synthesis problems of minimum order functional observers or fault detectors, or in computing minimal order inverses or minimal degree solutions of model matching problems.
Varga, Andreas
core  

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