Results 111 to 120 of about 9,489,153 (244)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Periodic solutions of non-autonomous second order systems with p-Laplacian
Electronic Journal of Differential Equations, 2009 We prove the existence of periodic solutions for non-autonomous second order systems with p-Laplacian. Our main tools are the minimax methods in critical point theory. Our results are new, even when p=2.
Jihui Zhang, Zhiyong Wang
doaj
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Anti-periodic solutions for second order differential inclusions
Electronic Journal of Differential Equations, 2004 In this paper, we extend the existence results presented in [9] for $L^{p}$ spaces to operator inclusions of Hammerstein type in $W^{1,p}$ spaces.
Jean-Francois Couchouron +1 more
doaj
Periodic solutions for second order differential equations with indefinite singularities
Advances in Nonlinear Analysis, 2019 In this paper, the problem of periodic solutions is studied for second order differential equations with indefinite ...
Lu Shiping, Yu Xingchen
doaj +1 more source
Almost Periodic Solutions of First-Order Ordinary Differential Equations
Mathematics, 2018 Approaches to estimate the number of almost periodic solutions of ordinary differential equations are considered. Conditions that allow determination for both upper and lower bounds for these solutions are found.
Seifedine Kadry +3 more
doaj +1 more source
The period functionsʼ higher order derivatives
Journal of Differential Equations, 2012 We prove a formula for the $n$-th derivative of the period function $T$ in a period annulus of a planar differential system. For $n = 1$, we obtain Freire, Gasull and Guillamon formula for the period's first derivative \cite{FGG}. We apply such a result to hamiltonian systems with separable variables and other systems.
openaire +3 more sources
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source