Results 111 to 120 of about 11,597,312 (305)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Balanced truncation model reduction of periodic systems [PDF]
, 2000 The balanced truncation approach to model reduction is considered for linear discrete-time periodic systems with time-varying dimensions. Stability of the reduced model is proved and a guaranteed additive bound is derived for the approximation error ...
Varga, Andras
core
, 2018 An event at time t = 0 triggers a poisson process. The solid curve shows the intensity of the proposed periodic point process with a Gaussian kernel and period τ, and the dashed curve shows a Hawkes process with an exponential decaying kernel.
Ali Zarezade (5264222) +2 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Complexity, 2018 Under investigation in this paper is a more general time-dependent-coefficient Whitham-Broer-Kaup (tdcWBK) system, which includes some important models as special cases, such as the approximate equations for long water waves, the WBK equations in shallow
Bo Xu, Sheng Zhang
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Heuristic Account and the Periodic Table [PDF]
, 2007 In this paper I criticise Worrall's heuristic account of use-novelty and his and Scerri's attempt (Worrall and Scerri 2001) to give support to this account by a case study of Mendeleev's periodic ...
Schindler, Samuel
core
Asymptotically periodic solutions of Volterra integral equations
Electronic Journal of Differential Equations, 2016 We study the existence of asymptotically periodic solutions of a nonlinear Volterra integral equation. In the process, we obtain the existence of periodic solutions of an associated nonlinear integral equation with infinite delay.
Muhammad N. Islam
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source