Results 81 to 90 of about 1,007,822 (327)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Periodic solutions of spatially periodic hamiltonian systems

Journal of Differential Equations, 1992
The existence of periodic solutions for Hamiltonian systems of ordinary differential equations (1) \(\dot z=J(H_ z(z,t)+f(t))\) is studied, where \(H: R^{2n}\times R\to R\) is of class \(C^ 1\) and is \(2\pi\)-periodic with respect to \(t\); \(f: R\to R\) is continuous and \(2\pi\)-periodic and \(J=\bigl({0 \atop I_ n} {-I_ n \atop 0}\bigr)\).
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Dynamical behaviors of a two-competitive metapopulation system with impulsive control

Advances in Difference Equations, 2017
In this paper, we study the dynamical behaviors of a two-competitive metapopulation system with impulsive control and focus on the stable coexistence of the superior and inferior species.
Shasha Tian, Yepeng Xing, Tao Ma
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dynamic Analysis of a Phytoplankton-Fish Model with Biological and Artificial Control

Discrete Dynamics in Nature and Society, 2014
We investigate a nonlinear model of the interaction between phytoplankton and fish, which uses a pair of semicontinuous systems with biological and artificial control. First, the existence of an order-1 periodic solution to the system is analyzed using a
Yapei Wang, Min Zhao, Xinhong Pan, Chuanjun Dai   +3 more
doaj   +1 more source

On some possible extensions of Massera's theorem

Electronic Journal of Qualitative Theory of Differential Equations, 2000
In this paper we consider ordinary and functional differential equations with $T$-periodic right hand side and look at some conjectures on proving the existence of a periodic solution.
Géza Makay
doaj   +1 more source

PERIODIC SOLUTIONS AND SLOW MANIFOLDS [PDF]

International Journal of Bifurcation and Chaos, 2007
After reviewing a number of results from geometric singular perturbation theory, we give an example of a theorem for periodic solutions in a slow manifold. This is illustrated by examples involving the van der Pol-equation and a modified logistic equation.
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

On the existence of periodic solution of perturbed generalized Li\'enard equations

, 2006
Under conditions of Levinson-Smith type, we prove the existence of a $\tau$-periodic solution for the perturbed generalized Li\'enard equation u''+\phi(u,u')u'+\psi(u)=\epsilon\omega(\frac{t}{\tau},u,u') with periodic forcing term.
Boussaada, Islam, Chouikha, A. Raouf
core   +1 more source