Results 91 to 100 of about 1,007,822 (327)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Almost-periodic solution for BAM neural networks [PDF]

open access: yesSurveys in Mathematics and its Applications, 2009
In this paper, we study the existence and uniqueness solution and investigate the conditions that make it almost-periodic solution for BAM neural networks with retarded delays.
Hamid A. Jalab, Rabha W. Ibrahim
doaj  

Some New Exact Solutions of (1+2)-Dimensional Sine-Gordon Equation

open access: yesAbstract and Applied Analysis, 2014
We use a generalized tanh function expansion method and a direct method to study the analytical solutions of the (1+2)-dimensional sine Gordon (2DsG) equation.
Wei-Xiong Chen, Ji Lin
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Periodic solution for ϕ-Laplacian neutral differential equation

open access: yesOpen Mathematics, 2019
This paper is devoted to the existence of a periodic solution for ϕ-Laplacian neutral differential equation as follows (ϕ(x(t)−cx(t−τ))′)′=f(t,x(t),x′(t)).$$\begin{array}{} (\phi(x(t)-cx(t-\tau))')'=f(t,x(t),x'(t)). \end{array}$$
Yao Shaowen, Cheng Zhibo
doaj   +1 more source

The Elusive Liapunov Periodic Solutions

open access: yesQualitative Theory of Dynamical Systems, 2015
We illustrate the use of regular and singular reduction methods in conjunction with classical perturbation theory to find periodic solutions of Hamiltonian systems. In particular, we use these methods to find families of periodic solutions when the classical Liapunov center theorem fails due to a resonance.
Meyer, Kenneth R.   +2 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy