Results 91 to 100 of about 768,044 (272)

The Elusive Liapunov Periodic Solutions

open access: yesQualitative Theory of Dynamical Systems, 2015
We illustrate the use of regular and singular reduction methods in conjunction with classical perturbation theory to find periodic solutions of Hamiltonian systems. In particular, we use these methods to find families of periodic solutions when the classical Liapunov center theorem fails due to a resonance.
Meyer, Kenneth R.   +2 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Variational Methods for Almost Periodic Solutions of a Class of Neutral Delay Equations

open access: yesAbstract and Applied Analysis, 2008
We provide new variational settings to study the a.p. (almost periodic) solutions of a class of nonlinear neutral delay equations. We extend Shu and Xu (2006) variational setting for periodic solutions of nonlinear neutral delay equation to the ...
M. Ayachi, J. Blot
doaj   +1 more source

Almost periodic processes and the existence of almost periodic solutions

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 1998
Some property which is equivalent to the concept of an asymptotically almost periodic integral for almost periodic processes is introduced. By using this property, it is shown that a precompact integral of almost periodic processes which is uniformly ...
Y. Hino, Satoru Murakami
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

The Traveling Wave Solutions and Their Bifurcations for the BBM-Like B(m,n) Equations

open access: yesJournal of Applied Mathematics, 2013
We investigate the traveling wave solutions and their bifurcations for the BBM-like B(m,n) equations ut+αux+β(um)x−γ(un)xxt=0 by using bifurcation method and numerical simulation approach of dynamical systems.
Shaoyong Li, Zhengrong Liu
doaj   +1 more source

A new integrable nonlocal modified KdV equation: Abundant solutions with distinct physical structures

open access: yesJournal of Ocean Engineering and Science, 2017
In this work we study a new integrable nonlocal modified Korteweg–de Vries equation (mKdV) which arises from a reduction of the AKNS scattering problem.
Abdul-Majid Wazwaz
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

A Novel Approach to a Time-Dependent-Coefficient WBK System: Doubly Periodic Waves and Singular Nonlinear Dynamics

open access: yesComplexity, 2018
Under investigation in this paper is a more general time-dependent-coefficient Whitham-Broer-Kaup (tdcWBK) system, which includes some important models as special cases, such as the approximate equations for long water waves, the WBK equations in shallow
Bo Xu, Sheng Zhang
doaj   +1 more source

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