Results 71 to 80 of about 768,044 (272)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Periodic Solutions Generated by Impulses for State-Dependent Impulsive Differential Equation

Discrete Dynamics in Nature and Society, 2015
We study the existence of periodic solutions for a class of state-dependent impulsive differential systems via geometrical analysis methods. Our results show that these periodic solutions are generated by impulses.
Qizhen Xiao, Binxiang Dai
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Periodic solutions in next generation neural field models. [PDF]

Biol Cybern, 2023
Laing CR, Omel'chenko OE.
europepmc   +1 more source

Periodic solutions of difference equations

Journal of Mathematical Analysis and Applications, 2003
For the difference equation \(x_{n+1}=\beta x_n- g(x_n)\) with \(\beta> 1\) and \(g(x)= \text{sign\,}x\) for \(x\neq 0\), \(g(0)= 1\), it is shown: For any \(m\in \mathbb{N}_0\) it has a \(2^m\)-periodic solution. If \(\beta^{2^m(2k+1)}- 2\beta^{2^m(2k-1)}\geq 1\) for \(k\in \mathbb{N}\) and some \(m\in\mathbb{N}\) it has a \((2k+1)2^m\)-periodic ...
Yi, Taishan, Zhou, Zhan
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The Existence of Periodic Solutions for Second-Order Delay Differential Systems. [PDF]

J Dyn Differ Equ, 2022
Liu C, Wang Q.
europepmc   +1 more source

Periodic solutions of periodically perturbed planar autonomous systems: A topological approach

, 2006
Aim of this paper is to investigate the existence of periodic solutions of a nonlinear planar autonomous system having a limit cycle x_0 of least period T_0>0 when it is perturbed by a small parameter, T_1-periodic, perturbation. In the case when T_0/T_1
Kamenskii, Mikhail, Makarenkov, Oleg, Nistri, Paolo   +2 more
core  

Periodic solutions of spatially periodic hamiltonian systems

Journal of Differential Equations, 1992
The existence of periodic solutions for Hamiltonian systems of ordinary differential equations (1) \(\dot z=J(H_ z(z,t)+f(t))\) is studied, where \(H: R^{2n}\times R\to R\) is of class \(C^ 1\) and is \(2\pi\)-periodic with respect to \(t\); \(f: R\to R\) is continuous and \(2\pi\)-periodic and \(J=\bigl({0 \atop I_ n} {-I_ n \atop 0}\bigr)\).
openaire   +1 more source