Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
On periodic solutions of a discrete Nicholson's dual system with density-dependent mortality and harvesting terms. [PDF]
Adv Differ Equ, 2021 Eswari R, Alzabut J, Samei ME, Zhou H.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
PERIODIC SOLUTIONS AND SLOW MANIFOLDS [PDF]
International Journal of Bifurcation and Chaos, 2007 After reviewing a number of results from geometric singular perturbation theory, we give an example of a theorem for periodic solutions in a slow manifold. This is illustrated by examples involving the van der Pol-equation and a modified logistic equation.
openaire +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Fractional Schrodinger-Poisson equations with general nonlinearities
Electronic Journal of Differential Equations, 2016 In this article we study the existence of positive solutions and ground state solutions for a class of fractional Schrodinger-Poisson equations in R^3 with general nonlinearity.
Ronaldo C. Duarte, Marco A. S. Souto
doaj
Dynamics of μ -piecewise pseudo almost periodic solutions of neutral-type inertial neural networks models: existence and attractiveness. [PDF]
Cogn Neurodyn, 2022 Ezzinbi K, Mbounja Béssémè F.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Complex network model for COVID-19: Human behavior, pseudo-periodic solutions and multiple epidemic waves. [PDF]
J Math Anal Appl, 2022 Silva CJ +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source