Results 81 to 90 of about 96,765 (260)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The Traveling Wave Solutions and Their Bifurcations for the BBM-Like B(m,n) Equations
Journal of Applied Mathematics, 2013 We investigate the traveling wave solutions and their bifurcations for the BBM-like B(m,n) equations ut+αux+β(um)x−γ(un)xxt=0 by using bifurcation method and numerical simulation approach of dynamical systems.
Shaoyong Li, Zhengrong Liu
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Complexity, 2018 Under investigation in this paper is a more general time-dependent-coefficient Whitham-Broer-Kaup (tdcWBK) system, which includes some important models as special cases, such as the approximate equations for long water waves, the WBK equations in shallow
Bo Xu, Sheng Zhang
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Periodic solutions of a delayed, periodic logistic equation
Applied Mathematics Letters, 2003 Consider the delay differential equation \[ {dN(t)\over dt}= N(t)[a(t)- b(t) N^p(t-\sigma(t))- c(t) N^q(t-\tau(t))],\tag{\(*\)} \] where \(a\), \(b\), \(c\), \(\tau\) are continuous \(\omega\)-periodic functions, \(p\) and \(q\) are positive constants.
openaire +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Exact Solutions of Travelling Wave Model via Dynamical System Method
Abstract and Applied Analysis, 2016 By using the method of dynamical system, the exact travelling wave solutions of the coupled nonlinear Schrödinger-Boussinesq equations are studied. Based on this method, the bounded exact travelling wave solutions are obtained which contain solitary wave
Heng Wang, Longwei Chen, Hongjiang Liu
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Periodic solutions for evolution equations
Electronic Journal of Differential Equations, 2002 We study the existence and uniqueness of periodic solutions for evolution equations. First we analyze the one-dimensional case. Then for arbitrary dimensions (finite or not), we consider linear symmetric operators.
Mihai Bostan
doaj
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source