Results 101 to 110 of about 784,955 (324)

Periodic Solutions for Nonlinear Integro-Differential Systems with Piecewise Constant Argument

open access: yesThe Scientific World Journal, 2014
We investigate the existence of the periodic solutions of a nonlinear integro-differential system with piecewise alternately advanced and retarded argument of generalized type, in short DEPCAG; that is, the argument is a general step function.
Kuo-Shou Chiu
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Variational Methods for Almost Periodic Solutions of a Class of Neutral Delay Equations

open access: yesAbstract and Applied Analysis, 2008
We provide new variational settings to study the a.p. (almost periodic) solutions of a class of nonlinear neutral delay equations. We extend Shu and Xu (2006) variational setting for periodic solutions of nonlinear neutral delay equation to the ...
M. Ayachi, J. Blot
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

The Traveling Wave Solutions and Their Bifurcations for the BBM-Like B(m,n) Equations

open access: yesJournal of Applied Mathematics, 2013
We investigate the traveling wave solutions and their bifurcations for the BBM-like B(m,n) equations ut+αux+β(um)x−γ(un)xxt=0 by using bifurcation method and numerical simulation approach of dynamical systems.
Shaoyong Li, Zhengrong Liu
doaj   +1 more source

Periodic, n-soliton and variable separation solutions for an extended (3+1)-dimensional KP-Boussinesq equation [PDF]

open access: gold, 2023
Chuanlin Shao   +5 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

A Novel Approach to a Time-Dependent-Coefficient WBK System: Doubly Periodic Waves and Singular Nonlinear Dynamics

open access: yesComplexity, 2018
Under investigation in this paper is a more general time-dependent-coefficient Whitham-Broer-Kaup (tdcWBK) system, which includes some important models as special cases, such as the approximate equations for long water waves, the WBK equations in shallow
Bo Xu, Sheng Zhang
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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