Results 71 to 80 of about 103,009 (314)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

A new integrable nonlocal modified KdV equation: Abundant solutions with distinct physical structures

open access: yesJournal of Ocean Engineering and Science, 2017
In this work we study a new integrable nonlocal modified Korteweg–de Vries equation (mKdV) which arises from a reduction of the AKNS scattering problem.
Abdul-Majid Wazwaz
doaj   +1 more source

Periodic solutions of a delayed, periodic logistic equation

open access: yesApplied Mathematics Letters, 2003
AbstractConsider the delayed periodic logistic equation, N(t)=N(t) [a(t)-b(t)Np(t-σ(t))-c(t)Nq(t−T(t))], which describes the evolution of a single species. The existence of a positive periodic solution is established by using the method of coincidence degree.
openaire   +2 more sources

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

open access: yesMolecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo   +11 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

On Stability of Periodic Solutions of Lienard Type Equations

open access: yesDiscrete Dynamics in Nature and Society, 2017
We use the Floquet theory to analyze the stability of periodic solutions of Lienard type equations under the asymptotic linear growth of restoring force in this paper.
Zijian Yin, Hongbin Chen
doaj   +1 more source

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