Results 121 to 130 of about 25,043 (257)

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti   +2 more
wiley   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni   +2 more
wiley   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder   +4 more
wiley   +1 more source

A Generalization Error Bound of Physics‐Informed Neural Networks for Ecological Diffusion Models

open access: yesStat, Volume 15, Issue 1, March 2026.
ABSTRACT Ecological diffusion equations (EDEs) are partial differential equations (PDEs) that model spatiotemporal dynamics, often applied to wildlife diseases. Derived from ecological mechanisms, EDEs are useful for forecasting, inference, and decision‐making, such as guiding surveillance strategies for wildlife diseases.
Juan Francisco Mandujano Reyes   +4 more
wiley   +1 more source

Characterizing Spatiotemporal Expansion of Pseudomonas aeruginosa Communities in Polymer and Mucin Gel Environments

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 2, Page 420-435, February 2026.
ABSTRACT Opportunistic colonization and recurring infection by Pseudomonas aeruginosa are substantial risks to lung functionality for people with underlying respiratory diseases such as cystic fibrosis and chronic obstructive pulmonary disease. The complex metabolic and phenotypic adaptations P.
Morgan S. Kim   +5 more
wiley   +1 more source

Sharp commutator estimates of all order for Coulomb and Riesz modulated energies

open access: yesCommunications on Pure and Applied Mathematics, Volume 79, Issue 2, Page 207-292, February 2026.
Abstract We prove functional inequalities in any dimension controlling the iterated derivatives along a transport of the Coulomb or super‐Coulomb Riesz modulated energy in terms of the modulated energy itself. This modulated energy was introduced by the second author and collaborators in the study of mean‐field limits and statistical mechanics of ...
Matthew Rosenzweig, Sylvia Serfaty
wiley   +1 more source

Dimer models and conformal structures

open access: yesCommunications on Pure and Applied Mathematics, Volume 79, Issue 2, Page 340-446, February 2026.
Abstract Dimer models have been the focus of intense research efforts over the last years. Our paper grew out of an effort to develop new methods to study minimizers or the asymptotic height functions of general dimer models and the geometry of their frozen boundaries.
Kari Astala   +3 more
wiley   +1 more source

Model‐Free Data‐Driven Computational Analysis for Soil Consolidation Problems

open access: yesInternational Journal for Numerical and Analytical Methods in Geomechanics, Volume 50, Issue 2, Page 1166-1175, 10 February 2026.
ABSTRACT Soils are inherently uncertain natural materials. In geotechnical engineering, soil properties are fundamentally characterised by testing small samples. The results will then be utilised to determine appropriate geomaterial constitutive models and associated parameters for implementation in conventional computational procedures such as finite ...
Wuzhou Zhai   +3 more
wiley   +1 more source

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