Results 131 to 140 of about 126,616 (274)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

open access: yesFEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner   +6 more
wiley   +1 more source

Exoplanets in the Antarctic Sky. V. The Second Data Release of AST3-II/CHESPA and Newly Found Variables within the Southern Continuous Viewing Zone of TESS

open access: yesThe Astrophysical Journal Supplement Series
Located at Dome A, the highest point on the Antarctic plateau, China’s Kunlun station is a premier ground-based photometric observatory. Its cold, dry, and stable atmosphere allows continuous observation for over 40 days during polar winter, ideal for ...
Bixuan Zhao   +15 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Minute-Cadence Observations of the LAMOST Fields with the TMTS: IV—Catalog of Cataclysmic Variables from the First 3-yr Survey

open access: yesUniverse
The Tsinghua University–Ma Huateng Telescopes for Survey (TMTS) started to monitor the LAMOST plates in 2020, leading to the discovery of numerous short-period eclipsing binaries, peculiar pulsators, flare stars, and other variable objects.
Qichun Liu   +26 more
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

A Spectroscopic and Photometric Study of MWC 342 and Its B[e] Phenomenon over the Last 40 Years

open access: yesGalaxies
MWC 342 (V1972 Cyg) was discovered nearly 90 years ago as an early-type emission-line star. It was among the first hot stars whose strong infrared excess was detected in the early 1970s.
Aigerim Zh. Akniyazova   +13 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

open access: yesFEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq   +3 more
wiley   +1 more source

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