Results 121 to 130 of about 72,602 (290)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Astronomical JournalCrater II (CraII) is a very intriguing low surface brightness and extended galaxy in the vicinity of our Galaxy. Motivated by its huge area and the number of RR Lyrae stars (RRLSs) detected near to its core, we performed a follow-up campaign to get deep ...
A. Katherina Vivas +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Heartbeat Stars Recognition Based on Recurrent Neural Networks: Method and Validation
The Astronomical JournalSince the variety of their light curve morphologies, the vast majority of the known heartbeat stars (HBSs) have been discovered by manual inspection. Machine learning, which has already been successfully applied to the classification of variable stars ...
Min-Yu Li +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Variable X-Ray Emission of the Planet Hosting T Tauri Star CI Tau
The Astronomical JournalWe report results of Chandra X-ray observations of CI Tau, a young magnetically active classical T Tauri star for which previous studies have reported periodic variability attributed to a massive planet in a short-period orbit.
Stephen L. Skinner, Manuel Güdel
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Plasma Torus around a Young Low-mass Star
The Astrophysical Journal LettersA small fraction of red dwarfs younger than ∼100 million years show structured, periodic optical light curves suggestive of transiting opaque material that corotates with the star. However, the composition, origin, and even the existence of this material
Luke G. Bouma, Moira M. Jardine
doaj +1 more source
Changes of Period in Variable Stars of Long Period [PDF]
Proceedings of the National Academy of Sciences, 1937 T E, Sterne, L, Campbell
openaire +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source