Results 111 to 120 of about 3,822 (305)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Random forest automated supervised classification of Hipparcos periodic variable stars
, 2016 We present an evaluation of the performance of an automated classification of the Hipparcos periodic variable stars into 26 types. The sub-sample with the most reliable variability types available in the literature is used to train supervised algorithms ...
L. Eyer +31 more
core
Characterization of variable stars by robust wave variograms: An application to Hipparcos mission
, 1999 Variogram analysis is applied to time series of variable stars. This method allows to characterize time-scales of varying signals. It is well suited for periodic and pseudo-periodic signals. The aspects of robustness, bin positions and bin widths for the
L. Eyer, M. G. Genton
core +1 more source
Revisiting γ-ray Orbital Modulation in the Redback Millisecond Pulsar PSR J2039−5617
The Astrophysical JournalPSR J2039−5617 is a redback millisecond pulsar binary system consisting of a compact star with a mass of 1.1–1.6 M _⊙ and a low-mass companion of 0.15–0.22 M _⊙ .
Mengqing Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
HAT discovery of 76 bright periodic variable stars toward the Galactic bulge
, 2016 We report on photometric I-band observations of 147 bright (8 < I < 13) periodic variable stars toward the Galactic bulge including 76 new discoveries. We used one of the HATnet telescopes to obtain 151 exposures spanning 88 nights in 2005 of an 8.°4
Nataf, David, Bakos, Gaspar, Stanek, K Z
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Near Continuous Photometry with the Whole Earth Telescope (WET)
Open Astronomy, 2003 The Whole Earth Telescope (WET) saw first light in 1988. It was invented by scientists from the Astronomy Department, University of Texas at Austin.
Solheim J. E.
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source