Results 91 to 100 of about 3,822 (305)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The Araucaria project. Bright variable stars in NGC 6822 from a wide-field imaging survey
, 2006 We have performed a search for variable stars in the dwarf irregular galaxy NGC 6822 using wide-field multi-epoch VI photometry down to a limiting magnitude $V \sim 22$. Apart from the Cepheid variables in this galaxy already reported in an earlier paper
I. Soszyński +3 more
core +1 more source
β Cephei Pulsators in Eclipsing Binaries Observed with TESS
The Astrophysical Journal Supplement SeriesThe combined strength of asteroseismology and empirical stellar basic parameter determinations for in-depth asteroseismic analysis of massive pulsators in eclipsing binaries shows great potential for treating the challenging and mysterious discrepancies ...
Christian I. Eze, Gerald Handler
doaj +1 more source
On the period of the variable Star V Puppis [PDF]
Astronomische Nachrichten, 1897 n ...
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Periodic variable A-F spectral type stars in the northern TESS continuous viewing zone
, 2022 Context. In the time of large space surveys that provide tremendous amounts of precise data, it is highly desirable to have a commonly accepted methodology and system for the classification of variable stars.
M. Fedurco +13 more
core +1 more source
Investigating the Potential of LS 5039 as a Triple System Using Fermi-LAT Data
The Astrophysical JournalLS 5039 is one of a handful of γ -ray binary systems in the milky Way, comprising a pulsar and a massive O-type companion star with an orbital period of 3.9 days.
Lujun Zeng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
A New Puzzling Periodic Signal in GeV Energies of the γ-Ray Binary LS I+61°303
The Astrophysical JournalLS I+61°303 is a high-mass X-ray binary system comprising a massive Be star and a rapidly rotating neutron star. Its spectral energy distribution across multiwavelengths categorizes it as a γ -ray binary system. In our analysis of LS I+61°303 using Fermi
Pengfei Zhang
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source