Results 81 to 90 of about 72,602 (290)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Search of Periodic Variable Stars in the LMC by JWST Photometry

The Astrophysical Journal Supplement Series
Based on high-resolution near-infrared photometric data from the James Webb Space Telescope (JWST) targeting the Large Magellanic Cloud, this study attempts to evaluate the feasibility and sensitivity limits of variable star detection in crowded stellar ...
Jiyu Wang, Xiaodian Chen, Jianxing Zhang, Ziming Yan, Shu Wang, Licai Deng   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Phase II of the LAMOST-Kepler/K2 Survey. II. Time Domain of Medium-resolution Spectroscopic Observations from 2018 to 2023

The Astrophysical Journal Supplement Series
The LAMOST-Kepler/K2 Medium-Resolution Spectroscopic Survey (LK-MRS) conducted time-domain (TD) medium-resolution spectroscopic observations of 20 LAMOST plates in the Kepler and K2 fields from 2018 to 2023, a phase designated as LK-MRS-I.
Mingfeng Qin, Jian-Ning Fu, Weikai Zong, Peter De Cat, Antonio Frasca, Tianqi Cang, Jiangtao Wang, Jianrong Shi, Ali Luo, Haotong Zhang, Hongliang Yan, J. Molenda-Żakowicz, R. O. Gray, Jiaxin Wang   +13 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Rotation Periods of Candidate Single Late-M Dwarfs in TESS

The Astronomical Journal
Recent studies suggest that the angular momentum evolution of late-M and brown dwarfs differs from the well-known spin-down evolution of hotter stars. Characterizing the distribution of rotation periods of these objects in the solar neighborhood can help
Samantha Lambier, Stanimir Metchev, Paulo Miles-Páez, Leslie Moranta, Dakota Wolfe, Joelene Hales, Jeffrey Martinovic   +6 more
doaj   +1 more source

ROTSE All Sky Surveys for Variable Stars I: Test Fields

, 2000
The ROTSE-I experiment has generated CCD photometry for the entire Northern sky in two epochs nightly since March 1998. These sky patrol data are a powerful resource for studies of astrophysical transients.
A. Pawl, B. Lee, C. Akerlof, D. Casperson, Feast M. W., Fernley J., G. Gisler, Hog E., J. Bloch, J. Hills, J. Schaefer, J. Szymanski, J. Wren, R. Balsano, R. Kehoe, S. Amrose, S. Fletcher, S. Marshall, T. McKay, Voges W.   +19 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Young Stellar Objects in the Carina Nebula: Near-infrared Variability and Spectroscopy

The Astronomical Journal
We present a catalog of 652 young stellar objects (YSOs) in the Carina star-forming region. The catalog was constructed by combining near-infrared K _S -band variability from the VISTA Variables in the Vía Láctea eXtended survey and medium-resolution H ...
Jura Borissova, Radostin Kurtev, Josemanuel Escobar, Javier Alonso-García, Nicolas Medina, Javier Osses, Zhen Guo, Philip W. Lucas, Michael Kuhn, Dante Minniti, Kevin R. Covey, Roberto K. Saito, Francisco Förster   +12 more
doaj   +1 more source