Results 101 to 110 of about 3,159 (265)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Variable X-Ray Emission of the Planet Hosting T Tauri Star CI Tau
The Astronomical JournalWe report results of Chandra X-ray observations of CI Tau, a young magnetically active classical T Tauri star for which previous studies have reported periodic variability attributed to a massive planet in a short-period orbit.
Stephen L. Skinner, Manuel Güdel
doaj +1 more source
Irregularities of Period of Long-Period Variable Stars [PDF]
Monthly Notices of the Royal Astronomical Society, 1929 A. S. Eddington, S. Plakidis
openaire +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Heartbeat Stars Recognition Based on Recurrent Neural Networks: Method and Validation
The Astronomical JournalSince the variety of their light curve morphologies, the vast majority of the known heartbeat stars (HBSs) have been discovered by manual inspection. Machine learning, which has already been successfully applied to the classification of variable stars ...
Min-Yu Li +9 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Plasma Torus around a Young Low-mass Star
The Astrophysical Journal LettersA small fraction of red dwarfs younger than ∼100 million years show structured, periodic optical light curves suggestive of transiting opaque material that corotates with the star. However, the composition, origin, and even the existence of this material
Luke G. Bouma, Moira M. Jardine
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
K2 Photometry and Long-Term Hα Variability in Four Previously Unreported Be Stars
UniverseClassical Be stars are key laboratories for investigating how rapid rotation, pulsations, and mass loss couple to the formation and evolution of circumstellar decretion disks.
Alan Wagner Pereira +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source