Results 101 to 110 of about 72,602 (290)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

β Cephei Pulsators in Eclipsing Binaries Observed with TESS

The Astrophysical Journal Supplement Series
The combined strength of asteroseismology and empirical stellar basic parameter determinations for in-depth asteroseismic analysis of massive pulsators in eclipsing binaries shows great potential for treating the challenging and mysterious discrepancies ...
Christian I. Eze, Gerald Handler
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Investigating the Potential of LS 5039 as a Triple System Using Fermi-LAT Data

The Astrophysical Journal
LS 5039 is one of a handful of γ -ray binary systems in the milky Way, comprising a pulsar and a massive O-type companion star with an orbital period of 3.9 days.
Lujun Zeng, Mengqing Zhang, Chongyang Ren, Pengfei Zhang, Jingzhi Yan   +4 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A New Puzzling Periodic Signal in GeV Energies of the γ-Ray Binary LS I+61°303

The Astrophysical Journal
LS I+61°303 is a high-mass X-ray binary system comprising a massive Be star and a rapidly rotating neutron star. Its spectral energy distribution across multiwavelengths categorizes it as a γ -ray binary system. In our analysis of LS I+61°303 using Fermi
Pengfei Zhang
doaj   +1 more source

Multi-band neural network classification of ZTF light curves as LSST proxies

Astronomy & Astrophysics
Context. Current and near-future sky survey programmes, such as the Legacy Survey of Space and Time (LSST) of the Vera C. Rubin Observatory, will produce vast amounts of data that will need new techniques to process them on reasonable timescales. Machine-
Szklenár T., Bódi A., Szabó R.
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Establishing Baselines for Six Short-period δ Scuti Variables

The Astronomical Journal
As part of our variable star follow-up program, we have examined a number of stars from the Asteroid Terrestrial-impact Last Alert System (ATLAS) survey. Using a combination of our own data, ATLAS data, and other archival data, we confirmed the published
Christiana Z. Suggs, Eric G. Hintz, Denise C. Stephens   +2 more
doaj   +1 more source