Results 131 to 140 of about 123,975 (308)

Who leads research productivity change? Guidelines for R&D policy-makers [PDF]

open access: yes
We rely on efficiency and productivity analysis based on Malmquist indices to evaluate to what extent policy-makers have been able to promote the creation and consolidation of comprehensive research groups that contribute to the implementation of a ...
Jiménez, Fernando   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Special Libraries, May-June 1957 [PDF]

open access: yes, 1956
Volume 48, Issue 5https://scholarworks.sjsu.edu/sla_sl_1957/1004/thumbnail ...
Special Libraries Association
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Upper extremity nerve lesions (diagnosis, indications, surgical techniques)

open access: yesSão Paulo Medical Journal
OBJECTIVE: Revision and questioning of orthodox principles regarding the conduction of nerve impulse. DESIGN: Retrospective study with clinical analysis of results.
Lauro Barros de Abreu
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

L'aportació espanyola a la producció científica internacional en biblioteconomia i documentació : un balanç de deu anys (1992–2001)

open access: yesBiD: Textos Universitaris de Biblioteconomia i Documentació, 2002
Es presenta una anàlisi de les publicacions dels investigadors espanyols, dins l’àmbit de la biblioteconomia i documentació (BiD), que han estat difoses a través de revistes internacionals, de manera que s’hi inclouen les que recullen les bases de dades ...
Jiménez Contreras, Evaristo
doaj  

Zehn Jahre «Bologna» in Spanien. Tagebuch eines Universitätslehrers [PDF]

open access: yes, 2009
Evaluation of the implantation of the so-called "Bologna Process" on the spanish University, according to the author's experience as Vicedean for Postgraduate Studies in the Law Faculty of the Universidad Complutense de Madrid.
Rodríguez Martín, José-Domingo
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

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