Results 91 to 100 of about 433,738 (330)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Periodization and its discontents [PDF]
Journal of Art Historiography, 2010 This essay originated as an editorial for an issue of Perspective devoted to periodization. It traces the critique and dismantling of this conception in art history, and argues that even most recent literature suggests that the problematic of ...
Thomas DaCosta Kaufmann
doaj
First-order expansion of homogenized coefficients under Bernoulli perturbations [PDF]
, 2013 Divergence-form operators with stationary random coefficients homogenize over large scales. We investigate the effect of certain perturbations of the medium on the homogenized coefficients.
Mourrat, Jean-Christophe
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Structuring of the periodization in antiquity: the Roman military training
Tanjungpura Journal of Coaching ResearchBackground and Study Aim. The sportive periodization originated from the military periodization of ancient civilizations and of the Greek Tetrad for the sportive preparation the ancient Greek athletes.
Nelson Kautzner Marques Junior
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
ON THE ISSUE OF RE-EVACUATION PROCESS PERIODIZATION
Вестник Кемеровского государственного университета, 2015 The subject of the research is the re-evacuation process. The purpose of the paper is to set forth and substantiate the author’s view of a very important and problematical component of the re-evacuation process – its periodization.
L. I. Snegireva
doaj
Frontiers in Physiology, 2019 Periodization schedules training periods according to predicted timings of cumulative adaptations and has been at the foundation of exercise prescription.
José Afonso +7 more
doaj +1 more source