Results 111 to 120 of about 48,314 (295)

CYCLICAL DYNAMICS OF TRANSPORT PRICING POLICY

Вестник университета, 2016
The article presents a periodization of the transport pricing policy in Russia, taking into account the dynamic properties of the world-system economic processes. The analysis of the main approaches to the periodization of the transport pricing policy is
T. Gainochenko
doaj  

Art history: formation of the academic discipline in Europe, and related developments in Greece (18th-19th c.) Rethymnon (3-4 October, 2014) [PDF]

Journal of Art Historiography, 2015
The Academic Forum with the title Art history: formation of the academic discipline in Europe and related developments in Greece (18th-19th centuries), co-organised by the Association of Greek Art Historians and the Institute for Mediterranean Studies ...
Annie Malama
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CYCLICAL DYNAMICS OF TRANSPORT PRICING POLICY

Вестник университета, 2019
The article presents a periodization of the transport pricing policy in Russia, taking into account the dynamic properties of the world-system economic processes. The analysis of the main approaches to the periodization of the transport pricing policy is
T. Gainochenko
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Henry Y. H. Zhao. The uneasy narrator : Chinese fiction from the traditional to the modern

, 1997
This article reviews the book The Uneasy Narrator: Chinese Fiction from the Traditional to the Modern , written by Henry Y.H ...
GE, Liangyan
core  

The Main Events of the First Period of Armed Conflict in the East of Ukraine (April - September 2014) [PDF]

Codrul Cosminului, 2018
The authors’ fundamental objective is to bring to the attention of the international academic community the results of the military-historical investigation on the main events of the armed conflict in eastern Ukraine.
Mykhailo Hrebeniuk, Valerii Hrytsiuk, Oleksandr Skriabin   +2 more
doaj