Results 61 to 70 of about 1,561,909 (341)

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells

Cellular Microbiology, 2016
Although human gingival epithelium prevents intrusions by periodontal bacteria, Porphyromonas gingivalis, the most well‐known periodontal pathogen, is able to invade gingival epithelial cells and pass through the epithelial barrier into deeper tissues ...
Hiroki Takeuchi, Akihiko Takada, M. Kuboniwa, A. Amano   +3 more
semanticscholar   +1 more source

Characterization of an α-L-fucosidase from the periodontal pathogen Tannerella forsythia

Virulence, 2015
The periodontal pathogen Tannerella forsythia expresses several glycosidases which are linked to specific growth requirements and are involved in the invasion of host tissues.
Z. A. Megson, Andrea Koerdt, H. Schuster, R. Ludwig, Bettina Janesch, Andrew M. Frey, K. Naylor, I. Wilson, Graham P. Stafford, P. Messner, C. Schäffer   +10 more
semanticscholar   +1 more source

Periodontal health [PDF]

, 2018
OBJECTIVES To date there is a paucity of documentation regarding definitions of periodontal health. This review considers the histological and clinical determinants of periodontal health for both intact and reduced periodontium and seeks to propose ...
P. Mark Bartold, Bartold, P.M., Lang, Niklaus Peter, Lang, Niklaus P, Niklaus P. Lang, Lang, N.P., Bartold, P Mark   +6 more
core   +2 more sources

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Assessment of Filifactor alocis and Porphyromonas gingivalis Levels in Subgingival Plaque of Patients with Type 2 Diabetes Mellitus with and without Periodontitis: A Case-Control Study

Journal of Clinical and Diagnostic Research
Introduction: Periodontitis, a chronic inflammatory condition, is influenced by microbial dysbiosis and the host’s immune response. Type 2 Diabetes Mellitus (T2DM) represents a significant public health challenge in India and exacerbates periodontal ...
Rajalakshmi Ashok Kumar, Ram Sabarish, Reshma Achu Joseph, Balaji Subbusamy Kanakasabapathy, Mohanapriya Chinambedu Dandapani   +4 more
doaj   +1 more source

Filifactor alocis — a new emerging periodontal pathogen

Microbes and infection, 2015
Filifactor alocis, a previously unrecognized Gram-positive anaerobic rod, is now considered a new emerging pathogen that may play a significant role in periodontal disease. F.
A. Aruni, A. Mishra, Y. Dou, O. Chioma, Brittany N. Hamilton, Hansel M. Fletcher   +5 more
semanticscholar   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Metatranscriptomic analysis of an in vitro biofilm model reveals strain-specific interactions among multiple bacterial species

Journal of Oral Microbiology, 2019
Interactions among bacteria can affect biofilm properties. Method: Here, we investigated the role of different bacteria in functional dysbiosis of an in vitro polymicrobial subgingival plaque model using both 16S rRNA and metatranscriptomic sequencing ...
Yifei Zhang, Wenyu Shi, Yeqing Song, Jinfeng Wang   +3 more
doaj   +1 more source

Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation.

Food & Function, 2015
Periodontitis (PD) is a chronic infectious disease mediated by bacteria in the oral cavity. (Poly)phenols (PPs), ubiquitous in plant foods, possess antimicrobial activities and may be useful in the prevention and management of periodontitis.
M. Shahzad, E. Millhouse, S. Culshaw, C. Edwards, G. Ramage, E. Combet   +5 more
semanticscholar   +1 more source