Results 111 to 120 of about 2,874,560 (299)

SIMILARITIES AND DIFFERENCES OF THE HYDROLOGICAL EXTREMES ON THE DUNA/DANUBE AND TISZA/TISA RIVERS (1921-2012) [PDF]

Aerul şi Apa: Componente ale Mediului, 2014
In terms of the water management in Hungary, both rivers have a highlighted importance, which is also indicated by the fact that 50-55% of the territory of the country is divided between the two catchment areas.
KONECSNY K., NAGY Z.
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Frost periods and frost-free periods in Poland and neighbouringcountries

Open Geosciences, 2015
The main objective of this article is to analysethe multiannual variability of frost occurrence and thelength of the frost-free period in Poland and neighbouringcountries between 1971 and 2010.
Tomczyk Arkadiusz M., Szyga-Pluta Katarzyna, Majkowska Agnieszka   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Influence of long-term episodic cyclic loading with rest periods on pipe-soil interaction

, 2022
Steel catenary risers (SCRs) are pipelines widely used for transporting hydrocarbon resources from subsea fields to floating structures. The assessment of long-term fatigue life of SCRs, especially at the section close to the touchdown zone, where ...
Christophe, Gaudin, Zhechen, Hou, Fauzan, Sahdi, Mark, Randolph   +3 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Holocene and Pleistocene pluvial periods in Yemen, Southern Arabia

, 2011
Arabia is an important potential pathway for the dispersal of Homo sapiens (“out of Africa”). Yet, because of its arid to hyper-arid climate humans could only migrate across southern Arabia during pluvial periods when environmental conditions were ...
Kramers, J., Abdulkarim Al-Subbary, Mangini, A., Mohammad Al-Aowah, Fleitmann, Dominik, Marek Pekala, Jan Kramers, Albert Matter, Al-Subbary, A., Fleitmann, D., Pekala, M., Stephen J. Burns, Matter, A., Augusto Mangini, Burns, S. J., Al-Aowah, M., Al-Subbary, A.A., Dominik Fleitmann, Burns, S.J.   +18 more
core   +1 more source

‘Early’ Texts in ‘Clear Script’ in the National Corpus of the Kalmyk Language: Chronological Characteristic

Oriental Studies, 2018
The article describes chronological characteristics of the written monuments in «Сlear Script». The development process of the peculiar Oirat (Kalmyk) literature, written in «Clear Script» can be divided into two periods.
E. Bembeev
doaj