Results 131 to 140 of about 2,473,933 (318)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Estimation of seepage losses from automated irrigation distribution channels during periods of shutdown [PDF]

, 2013
Irrigated agriculture is the largest water consumer all over the world as well as in Australia. Therefore, managing water more effectively in irrigation distribution systems is one of the most important and urgent challenges facing Australia. The correct
Moavenshahidi, Amirali
core  

Periodicity of Negation

Notre Dame Journal of Formal Logic, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

‘Early’ Texts in ‘Clear Script’ in the National Corpus of the Kalmyk Language: Chronological Characteristic

Oriental Studies, 2018
The article describes chronological characteristics of the written monuments in «Сlear Script». The development process of the peculiar Oirat (Kalmyk) literature, written in «Clear Script» can be divided into two periods.
E. Bembeev
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Countercyclical Price Movements during Periods of Peak Demand: Evidence from Grocery Retail Price for Avocados

Using a unique micro dataset and advanced panel models, this study examines the effects of demand shocks on grocery retail price for avocados, a key Californian fresh produce commodity.
Carman, Hoy F., Li, Lan, Sexton, Richard J.   +2 more
core  

Spruce tree-ring proxy signals during cold and warm periods

, 2017
The strength and temporal rigidity of climate signals are important characteristics of proxy data used to reconstruct climate variability over pre-instrumental periods. Here, we assess the performance of different tree-ring proxies, including ring width,
Esper, Jan, Jan Esper, Carnelli, Adriana L., Treydte, Kerstin, Leuenberger, Markus, Marc Filot, Kerstin Treydte, Markus Leuenberger, Kamenik, Christian, Christian Kamenik, Filot, Marc, Adriana L. Carnelli   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Temporally and genetically discrete periods of wheat sensitivity to high temperature

, 2017
Successive single day transfers of pot-grown wheat to high temperature (35/30oC day/night) replicated controlled environments, from the second node detectable to the milky-ripe growth stages, provides the strongest available evidence that the fertility ...
Barber, H. M., Gooding, M. J., Martin Lukac, Semenov, Mikhail A., James Simmonds, Semenov, M. A., Mikhail A. Semenov, Mike J. Gooding, Gooding, Mike J., Lukac, Martin, Henry M. Barber, Simmonds, J., Barber, Henry M., Lukac, M., Simmonds, James   +14 more
core   +1 more source