Results 41 to 50 of about 275,167 (299)

Designing the ideal perioperative pain management plan starts with multimodal analgesia. [PDF]

, 2018
Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual class-related side effects ...
Mariano, Edward R., Schwenk, Eric S.
core   +1 more source

Elective Open Suprarenal Aneurysm Repair in England from 2000 to 2010 an Observational Study of Hospital Episode Statistics [PDF]

, 2013
Background: Open surgery is widely used as a benchmark for the results of fenestrated endovascular repair of complex abdominal aortic aneurysms (AAA).
Alan Karthikesalingam, Alberto Vidal-Diez, Benjamin O. Patterson, CD Bicknell, CS Cina, E Choke, FA Lederle, GH Martin, Giuseppe Sollazzo, GL Gilling-Smith, J Cross, JA Cowan Jr, JA Cowan Jr, Jan D. Poloniecki, JC Parodi, JL De Bruin, JM Hacking, JM Richards, JN Armitage, Matthew M. Thompson, Peter J. E. Holt, Peter Whittaker, PJ Holt, PJ Holt, PJ Holt, RM Greenhalgh, Robert J. Hinchliffe, S Sinha, S Tsai, TP Sarac, V Jongkind, VI Patel   +31 more
core   +2 more sources

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

The impact of community-acquired critical sepsis on long-term mortality and morbidity—a nationwide cohort study

Scientific Reports
The long-term consequences of sepsis, including mortality and morbidity among survivors, are insufficiently understood. This nationwide matched cohort study investigated the association between presumed community-acquired critical sepsis (PCACS)and long ...
Ann-Charlotte Lindström, Jesper Eriksson, Mikael Eriksson, Erik von Oelreich, Johan Mårtensson, Emma Larsson, Anders Oldner   +6 more
doaj   +1 more source

Combined Intravenous Sildenafil and l-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow

Drugs in R&D, 2020
Background Endothelial dysfunction in the nitric oxide-cyclic guanosine monophosphate pathway is a potential contributor to perioperative myocardial ischemia.
Marek Brzezinski, Gabriela R. Dincheva, Kelsey Alloo, Celeste Wong, Chun-Miao Feng, Wynnis L. Tom, Ali Salahieh, Arthur W. Wallace   +7 more
doaj   +1 more source

Left atrial contraction strain and controlled preload alterations, a study in healthy individuals

Cardiovascular Ultrasound, 2022
Background In order to assess left atrial contractile function in disturbed circulatory conditions, it is necessary to have a clear understanding of how it behaves in a normal resting state with changes in loading conditions.
Peter Gottfridsson, Roman A’Roch, Per Lindqvist, Lucy Law, Tomi Myberg, Magnus Hultin, Alexander A’Roch, Michael Haney   +7 more
doaj   +1 more source

Impact of Radial Arterial Location on Catheter Lifetime in ICU Surgical Intensive Care

Critical Care Explorations, 2023
OBJECTIVES:. The use of arterial catheters is frequent in intensive care for hemodynamic monitoring of patients and for blood sampling, but they are often removed because of dysfunction.
Damien Marie, MD, Claire Dahyot-Fizelier, MD, PhD, Stéphanie Barrau, MD, Matthieu Boisson, MD, Denis Frasca, PhD, Angeline Jamet, MD, Stéphane Chauvet, MD, Nathan Ferrand, MD, Amélie Pichot, MD, Olivier Mimoz, MD, PhD, Thomas Kerforne, MD   +10 more
doaj   +1 more source

Postoperative pain management in children: Guidance from the pain committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative) [PDF]

, 2018
The main remit of the European Society for Paediatric Anaesthesiology (ESPA) Pain Committee is to improve the quality of pain management in children. The ESPA Pain Management Ladder is a clinical practice advisory based upon expert consensus to help to ...
Adamek, Akin, Al-Zaben, Alm, Amminnikutty, Amoli, Anderson, Anderson, Antila, Arcioni, Association of Paediatric Anaesthetists of Great Britain and Ireland, Aubrun, Aveline, Aysenur, Bailey, Bailie, Bakan, Baley, Becke, Beers, Bell, Ben-Meir, Bertini, Bhalla, Birmingham, Bouwmeester, Bozkurt, Breitfeld, Breschan, Breschan, Brown, Brown, Büttner, Carstensen, Cha, Chan, Chou, Conti, Cousins, Crellin, Cyna, Dadure, Dadure, Dahi-Taleghani, Dahmani, Dalens, Das, Derry, Derry, Duedahl, Ecoffey, El-Fattah, Elshammaa, Fendrich, Fieler, Finkel, Flack, Fösel, Ganidagli, Gear, Gemma, Ginsberg, Glover, Habre, He, Hicks, Hinz, Holmer Pettersson, Hong, Howard, Hudcova, Huenseler, Huynh, Höhne, Ingelmo, Ivani, Ivani, Ivani, Ivani, Jahr, Jaksch, José María, Ju, Jöhr, Kamata, Kart, Kimiaei Asadi, Kokki, Kokki, Kokki, Kokki, Koppert, Kost-Byerly, Kost-Byerly, Kubica-Cielińska, Kumar, Kurihara, Kwak, Lam, Laskowski, Lavonas, Leclair, Lee, Leksowski, Leoni, Litalien, Liu, Liu, Lorenzo, Lundeberg, Lönnqvist, Lönnqvist, Lönnqvist, Manworren, Marel, Marhofer, Mazoit, McNicol, Merry, Messerer, Messerer, Miller, Miró, Mobley, Mohammed, Momeni, Moriceau, Morton, Morton, Mukherjee, Müller, Mędrzycka-Dąbrowska, O'Sullivan, Olkkola, Orange, Ousley, Pace, Park, Park, Pasero, Petrat, Pierce, Polaner, Qian, Rabbitts, Redmann, Richer, Rugyte, Sahin, Sammartino, Sandeman, Schnabel, Schnabel, Schug, Schug, Schug, Schultz-Machata, Sekhavat, She, Shirazi, Sng, Soh, Sola, Soulard, Southworth, Sowder, Spacek, Splinter, Stamer, Staschen, Steans, Steffen, Subramanyam, Suresh, Taheri, Tobias, Tsuchiya, Valizadeh, Voepel-Lewis, Walker, Walther-Larsen, Walther-Larsen, Wang, Weintraud, Willschke, Willschke, Willschke, Wilson, Wilson-Smith, Wininger, Wong, Wong, Xue, Xue, Yaster, Yildiz, Yung   +196 more
core   +1 more source

Driving pressure during general anesthesia for open abdominal surgery (DESIGNATION) : study protocol of a randomized clinical trial [PDF]

, 2020
Background Intraoperative driving pressure (Delta P) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (V-T) is kept constant, Delta P may change according to positive end-expiratory pressure (PEEP)-induced
Aarts, Leon P. H. J., Akkerman, Ronald D. L., Albersen, Juliette J. E., Aurilio, Caterina, Battaglini, Denise, Boer, Christa, Boom, Annemieke, Brouwer, Tammo, Buhre, Wolfgang F. F. A., Bulte, Carolina S. E., de Abreu, Marcelo Gama, de Boer, Hans D., De Korte-de Boer, Dianne J., Edward-Rutten, Gitara M., Godfried, Marc B., Helmerhorst, Hendrik J. F., Hemmes, Sabrine N. T., Hofland, Jan, Hol, Liselotte, Hol, Liselotte, Hollmann, Markus W., Hoogenboom, Hester, Houweling, Bernard M., Huhn, Ragnar, In 't Veld, Bastiaan A., Konijn, Wanda, Koopman-van Gemert, Ankie W. M. M., Kortekaas, Minke C., Neto, Ary Serpa, Nijbroek, Sunny G. L. H., Pelosi, Paolo, Preckel, Benedikt, Rad, Mandana, Sansone, Pasquale, Schultz, Marcus J., Stamkot, Andre, Stolker, Robert Jan, Struys, Michel, Ten Hoope, W., Thiel, Bram, Ubben, Johannes F. H., van der Zwan, Tim, Van Lier, Felix, Wrigge, Hermann, Zeillemaker-Hoekstra, Miriam, Zwijsen, Johannes H. M. J.   +45 more
core   +3 more sources

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source