Results 31 to 40 of about 275,167 (299)

Predictors of weaning failure in case of VA ECMO implantation

Scientific Reports, 2022
The use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) for the treatment of refractory cardiogenic shock has increased significantly. Nevertheless, early weaning may be advisable to reduce the potential for severe complications.
Axelle Cusanno, Nadia Aissaoui, Vincent Minville, Jean Porterie, Caroline Biendel, Kim Volle, Laure Crognier, Jean-Marie Conil, Clément Delmas   +8 more
doaj   +1 more source

Business Process Redesign in the Perioperative Process: A Case Perspective for Digital Transformation [PDF]

, 2019
This case study investigates business process redesign within the perioperative process as a method to achieve digital transformation. Specific perioperative sub-processes are targeted for re-design and digitalization, which yield improvement. Based on a
Daily, Sandra, Doster, Barbara, Lewis, Carmen, Ryan, Jim   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Risk Factors of Intraoperative Dysglycemia in Elderly Surgical Patients [PDF]

, 2019
BACKGROUNDː Dysglycemia is associated with adverse outcome including increased morbidity and mortality in surgical patients. Acute insulin resistance due to the surgical stress response is seen as a major cause of so-called stress hyperglycemia. However,
Knaak, Cornelia, Kuenz, Sophia, Kurpanik, Maryam, Lachmann, Gunnar, Mörgeli, Rudolf, Spies, Claudia, Vorderwülbecke, Gerald, Windmann, Victoria, Wollersheim, Tobias   +8 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Longitudinal Analysis of Traditional Inflammatory Markers (IL-6, CRP) Juxtaposed With Heparin-Binding Protein (HBP) and Serum Amyloid A Protein Component (SAA) During Acute Infection and Convalescence From COVID-19 Infection in the Context of Initial Viral Load and Markers of Tissue Destruction

Journal of Immunology Research
Conclusions: The persistence of inflammatory markers suggests ongoing inflammatory responses post-COVID-19 infection. Significant heterogeneity observed in inflammatory responses upon admission indicates multiple distinct inflammatory phenotypes, which ...
Ahmed Sayed Ahmed, Mohamed A. Mahmoud, Hossam Gad, Mohamed Antar, Abdelhamed Elgazar, Vasishta Anil, Daniel A. Diedrich, Krzysztof Laudanski   +7 more
doaj   +1 more source

Assessment of pulmonary edema: principles and practice [PDF]

, 2018
Pulmonary edema increasingly is recognized as a perioperative complication affecting outcome. Several risk factors have been identified, including those of cardiogenic origin, such as heart failure or excessive fluid administration, and those related to ...
Assaad, Sherif, Friedman, Malcolm B., Kratzert, Wolf B., Perrino, Albert, Shelley, Benjamin   +4 more
core   +1 more source

Hybrid Magnetoactive Soft Elastomers: Material Development Toward Application in Diaphragm Pumps

Advanced Materials Technologies, EarlyView.
Hybrid magnetoactive soft elastomeric membranes are developed by combining two different types of magnetic particles. The membranes exhibit distinct mechanical, magnetic and thermal properties owing to the unique characteristics of the two magnetic particles.
Somashree Mondal, Paweł Orkisz, Bogdan Sapiński, Ralph Spolenak, Frank Clemens   +4 more
wiley   +1 more source

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Hauer, Daniela, Kilger, Erich, Schelling, Gustav, Schopp, Mirjam, Strewe, Claudia, Toth, Roland, Weis, Florian   +9 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source