Results 61 to 70 of about 5,647,953 (285)

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

open access: yesAdvanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang   +20 more
wiley   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

open access: yesAdvanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun   +15 more
wiley   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

open access: yesAdvanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li   +9 more
wiley   +1 more source

Unlocking Insights: A Survey on Perioperative Hemodynamic Monitoring in Kidney Transplantation Across India

open access: yesIndian Journal of Transplantation
Objective: Across the globe, kidney transplant is the most frequently performed transplant surgery. Suboptimal hemodynamic monitoring in the perioperative period results in poor graft and patient outcomes.
Vipin Kumar Goyal   +2 more
doaj   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

open access: yesAdvanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian   +7 more
wiley   +1 more source

ACUTE RENAL INJURY IN THE PERI-OPERATIVE PERIOD

open access: yesВестник анестезиологии и реаниматологии, 2018
Acute renal injury is a relatively new notion (introduced into the practice since 2012), which is currently understood as a fast failure of renal functions (within 48 hours) with increasing absolute rates of serum creatinine up to 26.5 mcmol/l and more ...
D. V. Sokolov, Yu. S. Polushin
doaj   +1 more source

Anaphylaxis during the perioperative period

open access: yesAnesthesia: Essays and Researches, 2012
The incidence of anaphylaxis during anesthesia has been reported to range from 1 in 4000 to 1 in 25,000. Anaphylaxis during anesthesia can present as cardiovascular collapse, airway obstruction, and/or skin manifestation. It can be difficult to differentiate between immune and nonimmune mast cell-mediated reactions and pharmacologic effects from the ...
openaire   +4 more sources

Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction

open access: yesAdvanced Science, EarlyView.
Overcoming the limitations of conventional grafts, a biomimetic trachea with two independent vascular pedicles enables rapid integration and sustained patency. This approach markedly improves survival rates, restores the epithelial barrier, and promotes regenerative pathways, presenting a transformative paradigm for clinical application.
Ziming Wang   +9 more
wiley   +1 more source

Massage in the application of perioperative medicine: research hotspots and trends

open access: yesFrontiers in Medicine
BackgroundOver the past decade, the application of massage in the perioperative period has attracted the interest of researchers worldwide, with a relatively stable volume of literature published annually.ObjectiveBy conducting a bibliometric analysis of
Xiaoqin Li   +5 more
doaj   +1 more source

SHOULD STATINS BE DISCONTINUED IN PERI-OPERATIVE PERIOD?

open access: yesВестник анестезиологии и реаниматологии, 2018
HMG-CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase inhibitors, which are more known as statins, reduce the level of low density lipoproteids and total cholesterol in blood plasma.
V. V. Lomivorotov   +3 more
doaj   +1 more source

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