Results 61 to 70 of about 1,975,428 (268)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Intraoperative 3D Navigation‐Guided Resection of Enlarged Transverse Process for Treating Bertolotti Syndrome Unresponsive to Noninvasive Treatments: Case Report

Clinical Case Reports
Bertolotti syndrome is a lumbosacral anomaly that induces persistent lumbar pain. This case describes 3D navigation‐guided resection of an enlarged transverse process.
Jakub Jankowski, Marcin Glin, Natalia Maślanek, Wiktoria Chyra, Agnieszka Pawełczyk, Maciej Radek   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Advances in Stem Cell Therapy for Diabetic Foot Ulcers

Diabetes, Metabolic Syndrome and Obesity
Bin Wang,1,2 Gang Zhao,2,3 Jiaqi Zhang,4 Wenyu Chen,2 Shanshan Yang,1 Yinuo Sun1 1Department of Surgery, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China ...
Wang B, Zhao G, Zhang J, Chen W, Yang S, Sun Y   +5 more
doaj  

Comparative analysis of surgical effectiveness between minimal invasive decompression and transforaminal lumbar interbody fusion in lumbar stenosis treatment

Brain and Spine, 2021
E. Brinyuk, N. Konovalov, A. Nazarenko, S. Kaprovoy, D. Asyutin, M. Shultz, R. Onoprienko, V. Korolishin, B. Zakirov, P. Zelenkov, A. Pogosyan, V. Rybakov   +11 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Comparison of the efficacy and safety of the posterior and paramedian minimally invasive approaches to ventral and ventro-lateral intradural extramedullary tumors

Brain and Spine, 2021
D. Asyutin, N. Konovalov, A. Nazarenko, R. Onoprienko, V. Korolishin, S. Kaprovoy, E. Brinyuk, A. Pogosyan, S. Timonin, B. Zakirov, M. Shultz, Y. Poluektov   +11 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Management of peripheral ossifying fibroma due to severe periodontitis: Case report [PDF]

Balkan Journal of Dental Medicine
Background/Aim: Peripheral ossifying fibroma (POF) constitutes a common reactive lesion of the gingiva, most commonly localized in the anterior maxillary region.
Zisis Stefanos, Zisi Vasileios, Shinas Nikolaos, Poulopoulos Konstantinos, Charisi Christina, Papadopoulos Petros, Kyriakou Nikolaos, Cordahi Joe, Anagnostou Eleftherios, Poulopoulos Athanasios   +9 more
doaj   +1 more source