Polyclonal and monoclonal B lymphocytes response in HCV-infected patients treated with direct-acting antiviral agents [PDF]
Hepatitis C virus (HCV) chronic infection can be associated with extrahepatic manifestations such as mixed cryoglobulinaemia and lymphoproliferative disorders that are endowed with increased rates of morbidity and all-cause mortality.
Burra, Patrizia +13 more
core +1 more source
Topical Menthol, Ice, Peripheral Blood Flow, and Perceived Discomfort [PDF]
Context : Injury management commonly includes decreasing arterial blood flow to the affected site in an attempt to reduce microvascular blood flow and edema and limit the induction of inflammation.
Jacks, Dean E. +2 more
core +2 more sources
Direct evidence for thymic function in adult humans. [PDF]
The understanding of human thymic function and evaluation of its contribution to T cell homeostasis are matters of great importance. Here we report the development of a novel assay to quantitate the frequency and diversity of recent thymic emigrants ...
Harris, JM +8 more
core +1 more source
Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]
BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves +7 more
core +4 more sources
About 10–40% of patients with osteoarthritis (OA) are not satisfied with the results of total arthroplasty (TA) of large joints. At the same time, the most common complication associated with the ineffectiveness of TA is postoperative pain (PP).Objective:
E. V. Chetina +6 more
doaj +1 more source
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module. [PDF]
Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). We present a resource to understand the molecular mechanisms that regulate BBB function in health and dysfunction during disease.
Aydin, Sidar +16 more
core +1 more source
Capillaroscopy in 2016 : new perspectives in systemic sclerosis [PDF]
Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc.
Cutolo, M +6 more
core +1 more source
Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis [PDF]
Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is ...
Agnoli, C +25 more
core +5 more sources
Many observational studies and experiments have found a strong association between lipid levels and adipokines and multiple myeloma (MM), but the causal relationship between lipid levels, adipokines and MM remains to be determined.
Yi Ding +4 more
doaj +1 more source
Ahmed Badar,1 Ayad Mohammed Salem,1 Abdullah Omar Bamosa,1 Hatem Othman Qutub,2 Rakesh Kumar Gupta,2 Intisar Ahmad Siddiqui3 1Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2Department of ...
Badar A +5 more
doaj

