Results 1 to 10 of about 250,250 (265)

Novel cell therapy with ex vivo cultured peripheral blood mononuclear cells significantly impacts angiogenesis in the murine ischemic limb model

Regenerative Therapy
Introduction: Autologous mononuclear cells (MNCs) have been used in vascular regenerative therapy since the identification of endothelial progenitor cells (EPCs).
Satomi Furukawa, Rie Hirano, Ai Sugawara, Satoshi Fujimura, Rica Tanaka   +4 more
doaj   +2 more sources

Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol‐associated hepatitis [PDF]

Clinical and Translational Medicine, 2023
Background Patients with acute alcohol‐associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence.
Annette Bellar, Nicole Welch, Jaividhya Dasarathy, Amy Attaway, Ryan Musich, Avinash Kumar, Jinendiran Sekar, Saurabh Mishra, Yana Sandlers, David Streem, Laura E Nagy, Srinivasan Dasarathy   +11 more
doaj   +2 more sources

Citrus pectin modulates chicken peripheral blood mononuclear cell proteome in vitro [PDF]

Poultry Science
: Citrus pectin (CP) is a dietary fiber used in animal nutrition with anti-inflammatory properties. CP downregulates chicken immunoregulatory monocytes' functions, like chemotaxis and phagocytosis, in vitro.
G. Ávila, M. Bonnet, D. Viala, S. Dejean, G. Grilli, C. Lecchi, F. Ceciliani   +6 more
doaj   +2 more sources

Density-Gradient Mediated Band Extraction of Leukocytes from Whole Blood Using Centrifugo-Pneumatic Siphon Valving on Centrifugal Microfluidic Discs. [PDF]

PLoS ONE, 2016
Here we present retrieval of Peripheral Blood Mononuclear Cells by density-gradient medium based centrifugation for subsequent analysis of the leukocytes on an integrated microfluidic "Lab-on-a-Disc" cartridge.
David J Kinahan, Sinéad M Kearney, Niamh A Kilcawley, Philip L Early, Macdara T Glynn, Jens Ducrée   +5 more
doaj   +1 more source

The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

Pharmaceutics, 2023
Hypertrophic scars can cause pain, movement restrictions, and reduction in the quality of life. Despite numerous options to treat hypertrophic scarring, efficient therapies are still scarce, and cellular mechanisms are not well understood.
Vera Vorstandlechner, Dragan Copic, Katharina Klas, Martin Direder, Bahar Golabi, Christine Radtke, Hendrik J. Ankersmit, Michael Mildner   +7 more
doaj   +1 more source

Low-Density Granulocyte Contamination From Peripheral Blood Mononuclear Cells of Patients With Sepsis and How to Remove It – A Technical Report

Frontiers in Immunology, 2021
Elucidating the mechanisms contributing to the dysregulated host response to infection as part of the syndrome is a current challenge in sepsis research. Peripheral blood mononuclear cells are widely used in immunological studies.
Judith Schenz, Manuel Obermaier, Sandra Uhle, Markus Alexander Weigand, Florian Uhle   +4 more
doaj   +1 more source

Population Pharmacokinetic Model of Plasma and Cellular Mycophenolic Acid in Kidney Transplant Patients from the CIMTRE Study

Drugs in R&D, 2020
Background and Objective Mycophenolate mofetil is widely used in kidney transplant recipients. Mycophenolate mofetil is hydrolysed by blood esterases to mycophenolic acid (MPA), the active drug.
François Riglet, Julie Bertrand, Aurélie Barrail-Tran, Céline Verstuyft, Hugues Michelon, Henri Benech, Antoine Durrbach, Valérie Furlan, Caroline Barau   +8 more
doaj   +1 more source

Immunological evaluation of patients with Alzheimer's disease based on mitogen-stimulated cytokine productions and mitochondrial DNA indicators

BMC Psychiatry, 2023
Background Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease.
Jiewen Huang, Zhen Song, Beiwen Wei, Qingtian Li, Ping Lin, Hui Li, Ke Dong   +6 more
doaj   +1 more source

Aggregation of mononuclear and red blood cells through an α4β1-Lu/basal cell adhesion molecule interaction in sickle cell disease

Haematologica, 2010
Background Abnormal interactions between red blood cells, leukocytes and endothelial cells play a critical role in the occurrence of the painful vaso-occlusive crises associated with sickle cell disease.
Vicky Chaar, Julien Picot, Olivier Renaud, Pablo Bartolucci, Ruben Nzouakou, Dora Bachir, Frédéric Galactéros, Yves Colin, Caroline Le Van Kim, Wassim El Nemer   +9 more
doaj   +1 more source

CD14+ cells from peripheral blood positively regulate hematopoietic stem and progenitor cell survival resulting in increased erythroid yield

Haematologica, 2015
Expansion of erythroblasts from human peripheral blood mononuclear cells is 4- to 15-fold more efficient than that of CD34+ cells purified from peripheral blood mononuclear cells.
Esther Heideveld, Francesca Masiello, Manuela Marra, Fatemehsadat Esteghamat, Nurcan Yağcı, Marieke von Lindern, Anna Rita F. Migliaccio, Emile van den Akker   +7 more
doaj   +1 more source