Results 181 to 190 of about 250,250 (265)

Supplementary Figures S1-S2 from Enhanced Antitumor Efficacy of Oncolytic Adenovirus–loaded Menstrual Blood–derived Mesenchymal Stem Cells in Combination with Peripheral Blood Mononuclear Cells

, 2023
Rafael Moreno‐Sánchez, Carlos Alberto Fajardo, Martí Farrera-Sal, Ana Judith Perisé-Barrios, Álvaro Morales‐Molina, Ahmed Abdullah Al-Zaher, Javier García‐Castro, Ramón Alemany   +7 more
openalex   +1 more source

Targeting of the CD161 Inhibitory Receptor Enhances Bone‐Marrow‐Resident Memory CD8+ T‐Cell‐Mediated Immunity against Multiple Myeloma

Advanced Science, EarlyView.
CD161 is identified as a novel inhibitory receptor on bone marrow (BM)‐resident CD8⁺ T cells in multiple myeloma (MM). Through interaction with its ligand CLEC2D, CD161 impairs T‐cell function and promotes immune suppression. Blockade of CD161 restores tissue residency and cytotoxicity of CD8⁺ T cells and enhances chimeric antigen receptor T‐cell (CAR ...
Liwen Wang, Linzhi Xie, Yi Zhou, Shiming Tan, Yan Yu, Qin Zhang, Xuefeng Chen, Yuhan Yan, Ruiheng Luo, Han Xiao, Qian Cheng, Jian Zhang, Ying Li, Erhua Wang, Tiebin Jiang, Jing Liu, Xin Li   +16 more
wiley   +1 more source

Population pharmacokinetics of tacrolimus whole blood and peripheral blood mononuclear cell concentrations in stable kidney-transplanted patients. [PDF]

Br J Clin Pharmacol
Agergaard K, Thiesson HC, Carstens J, Staatz CE, Järvinen E, Nielsen F, Christensen HD, Juhl-Sandberg R, Brøsen K, Stage TB, Andersen DT, Kjellsson MC, Bergmann TK.   +12 more
europepmc   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, EarlyView.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source

Extracellular traps in peripheral blood mononuclear cell fraction in childhood-onset systemic lupus erythematosus. [PDF]

Sci Rep
Saisorn W, Santiworakul C, Phuengmaung P, Siripen N, Rianthavorn P, Leelahavanichkul A.   +5 more
europepmc   +1 more source

Candidin and Trichophytin Stimulate the Production of Th1 and Regulatory Cytokines by Peripheral Blood Mononuclear Cells: Implication for Their Use as Adjuvants in Immunotherapy

, 2014
Ana Lúcia Moreno Amor, Leonardo Nascimento Santos, Alana Alcântara Galvão, Emília Maria Medeiros de Andrade Belitardo, Eduardo Santos da Silva, Neuza Maria Alcântara‐Neves, Lain Pontes–de-Carvalho   +6 more
openalex   +2 more sources

Tumor Cell‐Derived CXCL2 Potentiates Neutrophil‐Mediated Antitumor Immunity by Inhibiting Cholesterol Biosynthesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study identifies the unconventional role of CXCL2 in regulating neutrophil polarization and immune responses in HCC. Unlike the common view that CXCL2 acts mainly as an extracellular chemokine, intracellular CXCL2 can interact with YBX1 and prevent its nuclear translocation.
Xin Liu, Danli Yang, Qianqian Jiang, Meng Han, Zhao Zhou, Yukun Li, Yu Wu, Jingzhou Wang, Ting Zhang, Guohua Lou, Guochao Wei, Lin Wang, Fengmin Lu, Xiangmei Chen   +13 more
wiley   +1 more source

Use of serum-free media for peripheral blood mononuclear cell culture and the impact on T and B cell readouts. [PDF]

Front Toxicol
Cochrane S, Saib O, Sheffield D.
europepmc   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen   +13 more
wiley   +1 more source

Dual-release hydrocortisone treatment improves serum and peripheral blood mononuclear cell inflammatory and immune profiles in patients with autoimmune primary adrenal insufficiency. [PDF]

Front Immunol
Tomasello L, Coppola A, Pizzolanti G, Giordano C, Arnaldi G, Guarnotta V.   +5 more
europepmc   +1 more source