Results 191 to 200 of about 250,250 (265)

Millikelvin Intracellular Nanothermometry with Nanodiamonds

Advanced Science, EarlyView.
Nanothermometry in living cells is crucial for understanding heat diffusion and advancing cellular biology and drug discovery. Previous studies have reported controversial intracellular temperature variations. Using nanodiamond nanothermometry in macrophages, it is found that, in such experimental setting, apparent temperature changes are actually due ...
Maabur Sow, Jacky Mohnani, Genko Genov, Raphael Klevesath, Elisabeth Mayerhoefer, Yuliya Mindarava, Rémi Blinder, Soumen Mandal, Fabien Clivaz, Raúl B. Gonzalez, Daniel Tews, Christian Laube, Wolfgang Knolle, Amelie Jerlitschka, Farid Mahfoud, Oleg Rezinkin, Mateja Prslja, Yingke Wu, Pamela Fischer‐Posovszky, Martin B. Plenio, Susana F. Huelga, Tanja Weil, Anke Krueger, Gavin W. Morley, Oliver A. Williams, Steffen Stenger, Fedor Jelezko   +26 more
wiley   +1 more source

Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss. [PDF]

Nat Med
Petriti B, Rabiolo A, Chau KY, Williams PA, Montesano G, Lascaratos G, Garway-Heath DF.   +6 more
europepmc   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, EarlyView.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

A Means to an End(othelium): Using Peripheral Blood Mononuclear Cell 'Omics to Peer into the Pulmonary Vasculature. [PDF]

Ann Am Thorac Soc
Chiles JW.
europepmc   +1 more source

Whole transcriptome analysis of peripheral blood mononuclear cells from de novo and drug-naive Parkinson's disease patients

Francisco Navarrete, Marina Guillot-Fernández, Lorena Martínez-Hostyn, Daniela Navarro, Jose Antonio Molina, José P. López‐Atalaya, J. Manzanares   +6 more
openalex   +1 more source

Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ

, 2020
Susie Barbeau, Romain Desprat, B. Eymard, Cécile Martinat, Jean-Marc Lemaı̂tre, Claire Legay   +5 more
openalex   +2 more sources

An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy

Advanced Science, EarlyView.
This work develops an engineered probiotic consortium sensing pH, hypoxia, and lactate in the tumor microenvironment. It releases a lactate‐depleting enzyme (LdhA) and a PD‐L1 nanobody. In humanized mouse models (MC38 and HT‐29 tumors), it achieves durable oscillations, suppresses tumors, activates CD8+, CD4+, IFN‐γ+ T cells, and reduces Foxp3 ...
Yufei Guo, Mengxue Gao, Lina Wang, Haibin Yuan, Jianan Yin, Jiahao Wu, Xinran Gao, Zhixin Zhu, Yan Zhang, Zichen Wang, He Huang, Guangbo Kang   +11 more
wiley   +1 more source

Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis. [PDF]

Iran J Med Sci
Saipiyeva D, Askarov M, Jafari N, Zhankina R, Heath PR, Kozina L, Boltanova A, Omarbekov A, Ilyassov N, Tuganbekov T, Mussin NM, Kaliyev AA, Sultangereyev Y, Rahmanifar F, Mahdipour M, Bakhshalizadeh S, Shirazi R, Tanideh N, Tamadon A.   +18 more
europepmc   +1 more source

Long-term serum/plasma-free culture of human cytotoxic T lymphocytes induced from peripheral blood mononuclear cells

, 1994
S Q Liu, Reiko Shiba, B S Kim, Kaoru Saijo, Tadao Ohno   +4 more
openalex   +2 more sources

Overcoming EGFR‐Mediated Dendritic Cell Dysfunction to Enhance Anti‐tumor Immunity in EGFR‐Mutant NSCLC by Precisely Targeting CD73 With pH‐responsive Nanocarriers

Advanced Science, EarlyView.
EGFR mutations drive ERK/c‐Jun–mediated transcriptional activation of CD73, elevating adenosine levels and fostering an immunosuppressive TME by impairing DC maturation and CD8⁺ T cell priming. The pH‐responsive nanodrug F127ZIF‐8AB680 selectively inhibits CD73, normalizes adenosine metabolism, and re‐establishes effective anti‐tumor immunity ...
Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, Yanguo Liu   +14 more
wiley   +1 more source