Results 201 to 210 of about 250,250 (265)

Clinical validation of peripheral blood mononuclear cell DNA methylation markers for accurate early detection of hepatocellular carcinoma in Asian patients. [PDF]

Commun Med (Lond)
Cheishvili D, Wong C, Karim MM, Golam Kibria M, Jahan N, Chandra Das P, Khair Yousuf A, Islam A, Chandra Das D, Noor-E-Alam SM, Alam S, Rahman M, Khan WA, Al-Mahtab M, Szyf M.   +14 more
europepmc   +1 more source

TSH Ligand‐Based CAR‐T Cell Effectively Eradicates TSHR‐Positive Thyroid Cancer with Favorable Safety Profile

Advanced Science, EarlyView.
TSHR is highly expressed in differentiated thyroid cancer (DTC), making it an ideal target for adoptive immune cell therapy. A novel Ligand‐based TSH‐CAR‐T cell approach effectively eradicated TSHR‐positive thyroid tumors in vitro and accomplished full remission in tumor models with favorable safety profile, highlighting that TSH‐CAR‐T cells could ...
Fei Wang, Hui Zuo, Li Liu, Shiyuan Wang, Haifang Zhao, Zhao Liu, Gang Wang, Zhao Liu, Junnian Zheng, Chuan Xu, Hongwei Du   +10 more
wiley   +1 more source

Potential role of peripheral blood mononuclear cell ' s mitochondrial respiratory dysfunction in heart failure severity prediction in patients with cardioverter-defibrillator implantation indications. [PDF]

J Geriatr Cardiol
Atabekov TA, Krivolapov SN, Khlynin MS, Korepanov VA, Rebrova TY, Muslimova EF, Afanasiev SA, Batalov RE, Popov SV.   +8 more
europepmc   +1 more source

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

Advanced Science, EarlyView.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C. Christiani, Liming Liang, Leona D. Samson, Isaac A. Chaim, Zachary D. Nagel   +7 more
wiley   +1 more source

MARCO+ Tumor‐Associated Macrophages Impede CD8+ T Cell Immunity to Facilitate Immunotherapy Resistance in Renal Cell Carcinoma

Advanced Science, EarlyView.
MARCO+ TAMs dominate restrained cytotoxicity of CD8+ CTLs and ICB resistance in RCC. Mechanically, MARCO impairs MHC‐I‐mediated neoantigen cross‐presentation via the SOCS1‐JAK1‐STAT1‐NLRC5 signaling cascade in TAMs. Targeted MARCO treatment boosts macrophage antigen cross‐presentation and empowers CD8+ T cells, thereby potentiating ICB efficacy ...
Jiayuan Chen, Jiazhi Mo, Jinchang Wei, Mengnan Qu, Jie Dai, Yan Kong, Huayan Xu, Juan Li, Xieqiao Yan, Chuanliang Cui, Lu Si, Zhihong Chi, Jun Guo, Xiaowen Wu, Xinan Sheng   +14 more
wiley   +1 more source

Comparison of lipopolysaccharide-mediated peripheral blood mononuclear cell activation between Brahman and Brahman × Thai native crossbreed cattle. [PDF]

Vet World
Srinontong P, Aengwanich W, Somphon S, Khonwai S, Nitsinsakul T, Wu Z, Chalalai T, Saraphol B, Srisanyong W.   +8 more
europepmc   +1 more source

Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression

Advanced Science, EarlyView.
CD19‐293‐EV can switch the CD19 endocytosis pathway from clathrin‐mediated endocytosis to aggregation‐dependent endocytosis, leading to lysosomal degradation of the CD19/EVs complex. Degradation of the EVs leads to impairment in the IFN response and enhancement in EV uptake by target cells, creating a potent feedback cycle.
Zixuan Huang, Chaoqun Lu, Yixin Wang, Huajian Xian, Yuling Zheng, Ting Kang, Rufang Xiang, Shufeng Xie, Minghui Wang, Zeyi Li, Xiaoli Xia, Yaoyifu Yu, Wenjie Zhang, Huijian Zheng, Renyao Pan, Dan Li, Chunjun Zhao, Han Liu   +17 more
wiley   +1 more source

The Immune-Centric Revolution Translated into Clinical Application: Peripheral Blood Mononuclear Cell (PBMNC) Therapy in Diabetic Patients with No-Option Critical Limb-Threatening Ischemia (NO-CLTI)-Rationale and Meta-Analysis of Observational Studies. [PDF]

J Clin Med
Rehak L, Giurato L, Monami M, Meloni M, Scatena A, Panunzi A, Manti GM, Caravaggi CMF, Uccioli L.   +8 more
europepmc   +1 more source

Infected peripheral blood mononuclear cells transmit latent varicella zoster virus infection to the guinea pig enteric nervous system

, 2014
Lin Gan, Mingli Wang, Jason Chen, Michael D. Gershon, Anne A. Gershon   +4 more
openalex   +1 more source

Triple‐Negative Breast Cancer Cells Resist Natural Killer Cell‐Mediated Killing Through Interleukin‐11 Trans‐Signaling

Advanced Science, EarlyView.
Triple‐negative breast cancer cells express high levels of interleukin‐11 (IL‐11) that can form complexes with soluble IL‐11 receptor (sIL‐11R). These complexes can bind to gp130 on the membrane of natural killer (NK) cells through trans‐signaling to activate JAK1/STAT1/3/p21 downstream pathway.
Hongmei Yang, Hao Jia, Renfei Wu, Haibo Tong, Liping Chen, Kathy Qian Luo   +5 more
wiley   +1 more source