Results 211 to 220 of about 250,250 (265)

Single-cell sequencing reveals alterations in the peripheral blood mononuclear cell landscape and monocyte status during colorectal adenocarcinoma formation. [PDF]

Clin Transl Med
Xu J, Hu Y, Zhao J, Kong X, Xia S, Dai S, Ding L, Bu T, Cao Y, Liu M, Yan L, Xiao Q, Guo H, Yuan Y, Xu D, Ding K.   +15 more
europepmc   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

The Effect of Subclinical Ketosis on the Peripheral Blood Mononuclear Cell Inflammatory Response and Its Crosstalk with Depot-Specific Preadipocyte Function in Dairy Cows. [PDF]

Animals (Basel)
Ford HR, Mitchell TM, Scull T, Benitez OJ, Strieder-Barboza C.   +4 more
europepmc   +1 more source

Detection ofM. tuberculosisDNA in peripheral blood mononuclear cells of tuberculosis contacts does not associate with blood RNA signatures for incipient tuberculosis [PDF]

Joshua Rosenheim, Markos Abebe, Mulugeta Belay, Begna Tulu, Dawit Tayachew, Metasebia Tegegn, Sidra Younis, David A. Jolliffe, Abraham Aseffa, Gobena Ameni, Stephen T. Reece, Mahdad Noursadeghi, Adrian R. Martineau   +12 more
openalex   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

An ALS Assembly Modulator Signature in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics [PDF]

Shao Feng Yu, Maya Michon, Anuradha F. Lingappa, Kumar Paulvannan, Dennis Solas, Kim A. Staats, Justin K. Ichida, Debendranath Dey, Jeffrey Rosenfeld, Vishwanath R. Lingappa   +9 more
openalex   +1 more source

Nanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined

Aggregate, EarlyView.
Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...
Ling Mei, Xikai Wang, Zhuang Hu, Jierui Yan, Xiaobo Wang, Haoran Wang, Ya Hou, Pengfei Zhang, Qihang Ding   +8 more
wiley   +1 more source

Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine

Aggregate, EarlyView.
Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang, Yanyu Chen, Shile Wang, Kan Liu, Xing‐Zhong Zhao, Xiaobo Mao, Ben Zhong Tang, Lang Rao   +7 more
wiley   +1 more source

The Effect of Suplatast Tosilate on TARC Production in Peripheral Blood Mononuclear Cells and TARC Plasma Levels

, 2005
Shigeki Gorai, Nobuhisa Terada, Tadashi Kobayashi, Tomohiro Nomura, Woo Jeong Kim, Nobuyuki Onai, Kouji Matsushima, Akiyoshi Konno   +7 more
openalex   +1 more source

Leveraging the Mononuclear Phagocyte System for Advancing Glioma Theranostics: Current Insights and Future Directions

Aggregate, EarlyView.
Mononuclear phagocytic cells with their natural ability to cross the blood brain barrier may provide new possibilities for glioma diagnosis and treatment. This review focused on mechanistic insights of the role of mononuclear phagocyte system (MPS) in central nerve system and glioma development, as well as the critical evaluation of development ...
Wenhui Wang, Ruijing Wen, Qianbei Li, Zhen Cai, Zihao Ou, Lei Zheng   +5 more
wiley   +1 more source