Results 121 to 130 of about 298,696 (311)

Human cytomegalovirus productively infects primary differentiated macrophages [PDF]

, 1991
Monocytes are one of the predominant cell types in the peripheral blood that are infected by human cytomegalovirus (HCMV). Although virus can be detected in these cells in vivo, HCMV replication in cultured monocytes has been unsuccessful. In this study,
Schrier, R, Wiley, C, Nelson, J A, Ibanez, C E, Ghazal, P   +4 more
core  

Dendritic cells in human renal inflammation - Part II [PDF]

, 2011
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. Here, we review the available information on their role in human renal inflammation.
Elfriede Noessner, Noessner, Elfriede, Segerer, S., Noessner, E, Stephan Segerer, Nößner, E., Peter J. Nelson, Lindenmeyer, Maja, Segerer, Stephan, Lindenmeyer, M., Lindenmeyer, M, Nelson, P.J., Maja Lindenmeyer, Nelson, Peter J., Segerer, S, Nelson, P J   +15 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Synthesis of Th17 cytokines in the culture of peripheral blood mononuclear cells stimulated with Borrelia burgdorferi sensu lato [PDF]

, 2016
Introduction and objective Th17 lymphocytes and their cytokines, interleukin 17A (IL-17A), IL-17F and IL-22, participate in the response to extracellular bacteria and in the autoimmunity and may be engaged in the pathogenesis of Lyme borreliosis ...
Anna Moniuszko, Moniuszko, A., Dunaj, J., Czupryna, P., Grygorczuk, S., Renata Świerzbińska, Maciej Kondrusik, Joanna Zajkowska, Swierzbinska, R., Pancewicz, S., Sambor Grygorczuk, Zajkowska, J., Piotr Czupryna, Justyna Dunaj, Sławomir Pancewicz, Kondrusik, M.   +15 more
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Increased motility of mesenchymal stem cells is correlated with inhibition of stimulated peripheral blood mononuclear cells. [PDF]

, 2017
Immunomodulatory properties of mesenchymal stem cells (MSC) are key components of their successful applications in clinical setting. However, treatments based on MSC immunomodulation need understanding of cell characteristics before cell transplantation.
Bertolo, Alessandro, Baur, Martin, Stoyanov, Jivko, Pötzel, Tobias, Pavlicek, David, Gemperli, Armin   +5 more
core  

HEPATITIS-B VIRUS SPECIFIC TRANSCRIPTS IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS [PDF]

, 1992
We report on the analysis of HBV transcription in peripheral blood mononuclear cells of chronically infected patients by polymerase chain reaction amplification.
MANENTI, Federico, SCAGLIONI PP, VILLA, Erica, PASQUINELLI C, C. Pasquinelli, Margherita Melegari, P. P. Scaglioni, F. Manenti, Erica Villa, MELEGARI M   +9 more
core   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Impacts of CLA and dietary concentrate proportion on blood metabolite concentration and proliferation of peripheral blood mononuclear cells of periparturient dairy cows

Animal, 2015
The study aimed to examine effects of supplemented CLA to periparturient dairy cows receiving different concentrate proportions antepartum (a.p.) to investigate CLA effects on metabolism and immune function.
M. Petzold, U. Meyer, S. Kersten, J. Spilke, G. Breves, S. Dänicke   +5 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source