Results 11 to 20 of about 1,052,864 (307)

Measuring dose in lung identifies peripheral tumour dose inaccuracy in SBRT audit

Physica Medica, 2023
Stereotactic Body Radiotherapy (SBRT) for lung tumours has become a mainstay of clinical practice worldwide. Measurements in anthropomorphic phantoms enable verification of patient dose in clinically realistic scenarios. Correction factors for reporting dose to the tissue equivalent materials in a lung phantom are presented in the context of a national
Maddison Shaw, Jessica Lye, Andrew Alves, Joerg Lehmann, Masoumeh Sanagou, Moshi Geso, Rhonda Brown   +6 more
openaire   +2 more sources

Investigations of peripheral dose for helical tomotherapy

Zeitschrift für Medizinische Physik, 2013
Whenever treating a patient with percutaneous radiotherapy, a certain amount of dose is inevitably delivered to healthy tissue. This is mainly due to beam's entry and exit in the region of the target volume. In regions distant from the target volume, dose is delivered by leakage from the MLC and head scatter from the accelerator head and phantom ...
Steffen, Lissner, Kai, Schubert, Tilo, Wiezorek, Florian, Sterzing, Klaus, Herfarth, Gabriele, Sroka-Perez, Jürgen, Debus   +6 more
openaire   +2 more sources

Multiple-dose pharmacokinetics of telithromycin in peripheral soft tissues [PDF]

International Journal of Antimicrobial Agents, 2009
Based on clinicians' expectations of high concentrations of telithromycin (TEL) in tissues, combined with its excellent in vitro antimicrobial characteristics, TEL is casually considered as a potential therapeutic option for the therapy of minor cases of soft tissue or bite-wound infections.
Traunmüller, Friederike, Gattringer, Rainer, Fille, Manfred, Thallinger, Christiane, Joukhadar, Christian   +4 more
openaire   +2 more sources

A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours [PDF]

, 2016
Purpose: We performed a multi-centre phase I study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the orally available small molecule mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, WX-554, and to determine the ...
Allen, Rodger, Anthoney, Alan, Banerji, Udai, Bevan, Paul, Boddy, Alan V., Buerkle, Markus, Coyle, Vicky, Cresti, Nicola, Dean, Emma, Drew, Yvette, Evans, T.R. Jefferey, Greystoke, Alastair, Griffin, Melanie J., Jamieson, David, Mala, Carola, Merriman, Mark, Plummer, Ruth, Ranson, Malcolm, Rodgers, Lisa, Sludden, Julieann, Swales, Karen, Wilson, Richard H.   +21 more
core   +2 more sources

Low-dose direct fibrinolysis in peripheral vascular disease [PDF]

Journal of Vascular Surgery, 1984
One hundred thirty patients underwent low-dose, catheter-directed fibrinolytic therapy for arterial and graft occlusions present for various periods of time. In 65 consecutive patients the therapeutic parameters were identical, and a careful hematologic evaluation was performed.
B T, Katzen, K C, Edwards, A S, Albert, A, van Breda   +3 more
openaire   +2 more sources

Peripheral edema associated with low dose of pregabalin in an older person

Journal of Geriatric Mental Health, 2020
Peripheral edema has been reported as an adverse effect of various medications including antibiotics, nonsteroidal anti-inflammatory drugs, anti-hypertensive drugs, antipsychotics, etc., There are a limited number of cases reported the association of a ...
Shivanee Kumari, Aseem Mehra, Sandeep Grover   +2 more
doaj   +1 more source

Evaluation of the peripheral dose in stereotactic radiotherapy and radiosurgery treatmentsa) [PDF]

Medical Physics, 2010
PurposeThe main purpose of this work was to compare peripheral doses absorbed during stereotactic treatment of a brain lesion delivered using different devices. These data were used to estimate the risk of stochastic effects.MethodsTreatment plans were created for an anthropomorphic phantom and delivered using a LINAC with stereotactic cones and a ...
Erika, Di Betta, Laura, Fariselli, Achille, Bergantin, Federica, Locatelli, Antonella, Del Vecchio, Sara, Broggi, Maria Luisa, Fumagalli   +6 more
openaire   +2 more sources

Peripheral doses in patients undergoing Cyberknife treatment for intracranial lesions. A single centre experience

Radiation Oncology, 2011
Background Stereotactic radiosurgery/radiotherapy procedures are known to deliver a very high dose per fraction, and thus, the corresponding peripheral dose could be a limiting factor for the long term surviving patients.
Vlachopoulou Vassiliki, Antypas Christos, Delis Harry, Tzouras Argyrios, Salvaras Nikolaos, Kardamakis Dimitrios, Panayiotakis George   +6 more
doaj   +1 more source

Oxaliplatin-induced peripheral neuropathy can be minimized by pressurized regional intravascular delivery in an orthotopic murine pancreatic cancer model

Discover Oncology, 2022
Purpose There is a great need to reduce the toxicity of chemotherapy used in the management of pancreatic ductal adenocarcinoma (PDAC). Here we explore if regional pressurized delivery of oxaliplatin can minimize peripheral neuropathy in mice. Methods We
Jayanth Surya Narayanan Shankara Narayanan, Katie Frizzi, Suna Erdem, Partha Ray, David Jaroch, Bryan Cox, Steven Katz, Diego Vicente, Rebekah White   +8 more
doaj   +1 more source

Patient-Specific Fetal Dose Determination for Multi-Target Gamma Knife Radiosurgery: Computational Model and Case Report. [PDF]

, 2017
A 42-year-old woman at 29 weeks gestation via in vitro fertilization who presented with eight metastatic brain lesions received Gamma Knife stereotactic radiosurgery (GKSRS) at our institution. In this study, we report our clinical experience and a ...
Braunstein, Steve, Ma, Lijun, McDermott, Michael, Paulsson, Anna K, Phillips, Justin, Sneed, Patricia K, Theodosopoulos, Philip V   +6 more
core   +1 more source