Results 21 to 30 of about 671,786 (158)

Lung Locations Most Affected by Dose-Calculation Algorithms in CyberKnife Stereotactic Body Radiotherapy

IEEE Access, 2019
CyberKnife is a robotic stereotactic body radiotherapy (SBRT) system that precisely delivers large radiation doses to a target. Tissue heterogeneity and shape can be problems.
Yu-Jie Huang, Chih-Hsueh Lin, Hsiao-Han Chang, Hui-Min Ting, Pei-Ju Chao, I-Hsing Tsai, Chao-Hong Liu, Chun-Chieh Huang, Tsair-Fwu Lee   +8 more
doaj   +1 more source

Influence of target dose heterogeneity on dose sparing of normal tissue in peripheral lung tumor stereotactic body radiation therapy

Radiation Oncology, 2021
Objective To evaluate the influence of target dose heterogeneity on normal tissue dose sparing for peripheral lung tumor stereotactic body radiation therapy (SBRT).
Zhigong Wei, Xingchen Peng, Yan Wang, Lianlian Yang, Ling He, Zheran Liu, Jingjing Wang, Xiaoli Mu, Ruidan Li, Jianghong Xiao   +9 more
doaj   +1 more source

Cisplatin-lnduced peripheral neurotoxicity is dependent on total-dose intensity and single-dose intensity [PDF]

Cancer, 1992
The authors prospectively evaluated the effects of three different schedules of cisplatin (DDP) administration in 60 patients with advanced epithelial ovarian cancer. The individual total dose of DDP was 450 mg/m2 in all three groups, and the anti-cancer response at the end of treatment was similar for the different regimens.
Cavaletti, GA, Marzorati, L, Bogliun, G, Colombo, N, Marzola, M, Pittelli, MR, Tredici, G   +6 more
openaire   +3 more sources

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

Journal of Translational Medicine, 2008
Background LXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR activation causes upregulation of genes involved in reverse cholesterol transport (RCT), including ABCA1 and ABCG1 transporters, in ...
Mounts William M, Wang Shuguang, Savio Dawn, Nambi Ponnal, Liu Qiang-Yuan, Halpern Anita R, Feingold Irene, Chen Liang, Basso Michael D, Kornaga Tad, Evans Mark J, Quinet Elaine M, Arai Maya, DiBlasio-Smith Elizabeth A, Isler Jennifer A, Slager Anna M, Burczynski Michael E, Dorner Andrew J, LaVallie Edward R   +18 more
doaj   +1 more source

Dose prescription with spatial uncertainty for peripheral lung SBRT [PDF]

Journal of Applied Clinical Medical Physics, 2018
AbstractCurrent clinical practice is to prescribe to 95% of the planning target volume (PTV) in 4D stereotactic body radiotherapy (SBRT) for lung. Frequently the PTV margin has a very low physical density so that the internal target volume (ITV) receives an unnecessarily high dose. This study investigates the alternative of prescribing to the ITV while
Bedford, JL, Blasiak-Wal, I, Hansen, VN
openaire   +3 more sources

Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients

Brazilian Journal of Medical and Biological Research, 2005
FTY720 is a new and effective immunosuppressive agent, which produces peripheral blood lymphopenia through a lymphocyte homing effect. We investigated the relationship between the dose of FTY720 or blood concentration (pharmacokinetics, PK) and ...
S.I. Park, C.R. Felipe, P.G. Machado, R. Garcia, A. Skerjanec, R. Schmouder, H. Tedesco-Silva Jr., J.O. Medina-Pestana   +7 more
doaj   +1 more source

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

eLife, 2017
Chemotherapy-induced peripheral neuropathy (CIPN) arises from collateral damage to peripheral afferent sensory neurons by anticancer pharmacotherapy, leading to debilitating neuropathic pain.
Peter M LoCoco, April L Risinger, Hudson R Smith, Teresa S Chavera, Kelly A Berg, William P Clarke   +5 more
doaj   +1 more source

Low Dose-Rate Irradiation of Gamma-Rays-Induced Cytotoxic and Genotoxic Alterations in Peripheral Erythrocytes of p53-Deficient Medaka (Oryzias latipes)

Frontiers in Marine Science, 2021
Morphological alterations and nuclear abnormalities in fish erythrocytes have been used in many studies as bioindicators of environmental mutagens including ionizing radiation.
Alaa El-Din H. Sayed, Alaa El-Din H. Sayed, Kento Nagata, Kento Nagata, Takuya Nakazawa, Hiroshi Mitani, Junya Kobayashi, Junya Kobayashi, Shoji Oda   +8 more
doaj   +1 more source

Feasibility of low dose chest CT for virtual bronchoscopy navigation in a porcine model

Respiratory Research, 2019
Background Virtual bronchoscopy navigation (VBN) is widely used for assistance in the histological examination of lung nodules. However, little is known about the optimal CT radiation dose for VBN.
Insu Kim, Geewon Lee, Jung Seop Eom, Hyo Yeong Ahn, Ahreum Kim   +4 more
doaj   +1 more source

Low-dose peripheral blood stem cell graft after high-dose chemotherapy - an evaluation of hematopoietic reconstitution

BMC Cancer, 2020
Background High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients.
Sandra Sauer, Petra Pavel, Anita Schmitt, Martin Cremer, Mark Kriegsmann, Thomas Bruckner, Karin Jordan, Patrick Wuchter, Carsten Müller-Tidow, Katharina Kriegsmann   +9 more
doaj   +1 more source