Results 161 to 170 of about 174,818 (267)

Collagen epineurial substitute-assisted neurorrhaphy is superior to conventional end-to-end neurorrhaphy in a rat model of peripheral nerve injury. [PDF]

J Orthop Translat
Wang Y, Pletikosa Z, Chen P, Li J, Chen Z, Bright C, Chu S, O'Beirne A, Brogan D, Kennedy BF, Hoyen H, Li H, Li D, Lee C, Chen L, Ruan R, Zheng M.   +16 more
europepmc   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

The Role of the Gut Microbiota in Functional Recovery after Peripheral Nerve Injury: A Narrative Review. [PDF]

Orthop Rev (Pavia)
Mueller MK, Rousseau SR, Hark GM, Shaffer LR, Rizvanović BF, Nuelle JAV.   +5 more
europepmc   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

The fate of the neuromuscular junction in peripheral nerve injury - current understanding and future research aims: A scoping review. [PDF]

JPRAS Open
Overland J, Savage A, Savage N, LaLiberte C, Dingle A, Shukla L.   +5 more
europepmc   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

A hydrogel ionic circuit electrical stimulation system to restore denervated muscle following long-gap peripheral nerve injury. [PDF]

Bioact Mater
Alimi OA, Kuss M, Kilic SG, Sun M, Salati A, Wan S, Argyropoulos C, Zhao F, Tu H, Wang HJ, Gao L, Kong Y, Liu B, Krishnan MA, Pan T, He Z, Li Y, Wu Y, DiMaio DJ, Li YL, Deegan PT, Desyatova A, Kamenskiy A, Zhao S, Duan B.   +24 more
europepmc   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source