Results 241 to 250 of about 291,176 (356)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Mesenchymal stem cell-laden double-network hydrogel nerve guidance conduits for peripheral nerve injury repair. [PDF]

Bioact Mater
Kim J, Park J, Lee S, Ryu C, Yi J, Choe G, Jo C, Lee JY.   +7 more
europepmc   +1 more source

CXCR2 mediated trafficking of neutrophils and neutrophil extracellular traps are required for myelin clearance after a peripheral nerve injury [PDF]

Brian Balog, Jon P. Niemi, Thomas Disabato, Faye Hashim, Richard E. Zigmond   +4 more
openalex   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

A Thermo-Photo-Ionic Crosslinked Gellan Gum Hydrogel with Gradient Biomechanic Modulation as a Neuromaterial for Peripheral Nerve Injury. [PDF]

Gels
Khatib S, Ramburrun P, Choonara YE.
europepmc   +1 more source

Injectable and In Situ Hydration‐Reinforced Hybrid Bone Cements for Accelerated Bone Regeneration

Advanced Science, EarlyView.
To enable minimally invasive bone defect repair, an injectable and hydration‐reinforced bone cement (L‐PEGS/CPC) is designed through biomimetic reconstruction. The hydrophilic L‐PEGS organic phase provides abundant nucleation sites, synergizing with its porous architecture to accelerate CPC hydration, thereby endowing the composite with exceptional ...
Xing Chen, Yifan Ma, Lingfei Zhao, Lingbin Che, Dianwen Song, Zihan Wu, Changsheng Liu, Yuan Yuan   +7 more
wiley   +1 more source

Scorpion (Hottentotta tamulus) venom pre-exposure delays functional recovery in mice following peripheral nerve injury. [PDF]

PLoS One
Khan A, Raza C, Zahid MT, Rehman HFU, Sharif S, Khan KU.   +5 more
europepmc   +1 more source

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

, 2016
Yong Liu, Li‐Jun Zhou, Wang Jun, Dai Li, Wen-Jie Ren, Jiyun Peng, Wei Xiao, Ting Xu, Wen‐Jun Xin, Rui-Ping Pang, Yong-Yong Li, Zhihai Qin, Madhuvika Murugan, Mark P. Mattson, Long‐Jun Wu, Xian‐Guo Liu   +15 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Ptbp1 Knockdown in Glial Cells Promotes Motor and Sensory Function Recovery After Peripheral Nerve Injury. [PDF]

CNS Neurosci Ther
Song H, Peng L, Chen D, Fan X, Hua T, Ding R, Deng M, Chen Q, Yang M, Yuan H.   +9 more
europepmc   +1 more source