Results 61 to 70 of about 290,293 (314)

Aligned cellular and acellular collagen guidance substrates for peripheral nerve repair [PDF]

, 2011
There is a clinical demand to shorten the delay of reinnervation and improve functional recovery after peripheral nerve injury. A peripheral nerve repair device with the ability to direct and promote axon growth across a lesion would be a promising ...
Georgiou, Melanie, Golding, Jon, Loughlin, Jane, Phillips, James   +3 more
core  

Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy : pain relief and neuroprotection share a PPAR-alpha-mediated mechanism [PDF]

, 2013
Peer reviewedPublisher ...
Calignano, A, D'Agostino, G, Di Cesare Mannelli, L, Ghelardini, C, Pacini, A, Russo, R, Zanardelli, M   +6 more
core   +4 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Learning and memory with neuropathic pain: impact of old age and progranulin deficiency [PDF]

, 2013
Persistent neuropathic pain is a frequent consequence of peripheral nerve injuries, particularly in the elderly. Using the IntelliCage we studied if sciatic nerve injury obstructed learning and memory in young and aged mice, each in wild type and ...
Albuquerque, Boris, Häussler, Annett, Tegeder, Irmgard, Vannoni, Elisabetta, Wolfer, David P   +4 more
core   +2 more sources

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Single-cell profiling of cellular changes in the somatic peripheral nerves following nerve injury

Frontiers in Pharmacology
Injury to the peripheral nervous system disconnects targets to the central nervous system, disrupts signal transmission, and results in functional disability.
Li Zhao, Chunyi Jiang, Bin Yu, Jianwei Zhu, Yuyu Sun, Sheng Yi   +5 more
doaj   +1 more source

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. [PDF]

, 2013
BackgroundSpinal Toll-like receptors (TLRs) and signaling intermediaries have been implicated in persistent pain states. We examined the roles of two major TLR signaling pathways and selected TLRs in a mononeuropathic allodynia.MethodsL5 spinal nerve ...
A Ledeboer, AI de la Llave-Rincon, AL Oaklander, AS Jaggi, BJ Marsh, C Erridge, C Fernandez-de-las-Penas, C Fernandez-de-las-Penas, CA Christianson, CC Bowman, CF Kim, CI Svensson, CR Stewart, CS Jack, D Kim, D Kim, F Kozin, F Marchand, FY Tanga, H Cao, H Hacker, H Hashizume, H Tsujino, H Yanai, I Bettoni, J Mika, J Zhang, JA DeLeo, JA Stokes, JA Stokes, Jennifer A Stokes, JL Hylden, JM Chung, Jonathan Cheung, K Hoebe, K Honda, K Hoshino, K Kariko, KA Cavassani, Kelly Eddinger, KH Konopka, L Cao, L Nicotra, L Znaor, LA O’Neill, LA Panagio, LH Guo, M Bsibsi, M Calvo, M Chacur, M Hossaini, M Koltzenburg, M Yamamoto, Maripat Corr, MR Hutchinson, MR Hutchinson, NE Saade, O Adachi, O Saito, O Takeuchi, P Hu, P Hu, Q Xu, Q Zhang, R Wang, RE Sorge, RG Chen, RG Zanon, S Akira, S Akira, S Hosmane, S Lehnardt, S Nadeau, S Pu, S Rivest, S Sakaguchi, SR Chaplan, SW Mitchell, T Kawai, T King, T Liu, T Shichita, T Tanaka, Tony L Yaksh, TW Vanderah, V Huge, V Raghavendra, V Raghavendra, XY Hua, Y Ohmichi, YR Wen   +90 more
core   +1 more source

Thrombin regulates the ability of Schwann cells to support neuritogenesis and to maintain the integrity of the nodes of Ranvier [PDF]

, 2020
Schwann cells (SC) are characterized by a remarkable plasticity that enables them to promptly respond to nerve injury promoting axonal regeneration. In peripheral nerves after damage SC convert to a repair-promoting phenotype activating a sequence of ...
Ciraci, Viviana, De Franchis, Valerio, Fabrizi, Cinzia, Familiari, Giuseppe, Familiari, Pietro, Fumagalli, Lorenzo, Leone, Stefano, Matassa, Roberto, Pompili, Elena, Tata, Ada Maria   +9 more
core   +2 more sources

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source