Results 221 to 230 of about 118,363 (344)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Bioresorbable, wireless dual stimulator for peripheral nerve regeneration. [PDF]

Nat Commun
Ahn HY, Walters JB, Avila R, Oh S, Seo SG, Kim JU, Park J, Yoo S, Choi YS, Kim TY, Liu J, Yoo JY, Weissleder OR, D'Andrea D, Park C, Lee G, Cho D, Maeng WY, Yoon HJ, Wickerson G, Bouricha Y, Tian J, Chung TC, Jordan SW, Li S, Huang Y, Franz CK, Rogers JA.   +27 more
europepmc   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

Advances in mesenchymal stem cells and their derivatives for promoting peripheral nerve regeneration. [PDF]

Burns Trauma
Wei S, Dong J, Hu Q, Bai J, Gao X, Shan H, Sheng L, Dai J, Tao L, Yan B, Zhou X.   +10 more
europepmc   +1 more source

Neuromodulatory nerve regeneration: Adipose tissue‐derived stem cells and neurotrophic mediation in peripheral nerve regeneration

, 2013
Alan D. Widgerow, Ara A. Salibian, Shadi Lalezari, Gregory R. D. Evans   +3 more
openalex   +2 more sources

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

Schwann cells modified to secrete MANF is a potential cellular therapy for peripheral nerve regeneration. [PDF]

Cell Regen
Sivakumar B, Hammond C, Martinez V, Joseph N, John JV, Kumar A, Krishnan A.   +6 more
europepmc   +1 more source

Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia [PDF]

, 2019
Carlin, Dan, Cavalli, Valeria, Ewan, Eric E, Halevi, Alexandra E, Moore, Amy M   +4 more
core   +1 more source

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration. [PDF]

Burns Trauma
Song J, Yuan Z, Yu X, Shen Y, Wu J, Sun B, Qin CX, El-Newehy M, Mo X, Gu H.   +9 more
europepmc   +1 more source